Effect of D-ribose-L-cysteine on aluminum induced testicular damage in male Sprague-Dawley rats

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dc.contributor.authorFalana, B
dc.contributor.authorAdeleke, O
dc.contributor.authorOrenolu, M
dc.contributor.authorOsinubi, A.A
dc.contributor.authorOyewopo, A
dc.date.accessioned2022-01-14T14:24:36Z
dc.date.available2022-01-14T14:24:36Z
dc.date.issued2017
dc.description.abstractObjective: This study investigated the effects of D-ribose and L-cysteine on aluminum-induced testicular damage in male Sprague-Dawley rats. Method: A total number of thirty-five (35) adult male Sprague-Dawley rats were divided into four groups (A- D). Group A (comprised five (5) rats) was designated the Control Group that received Physiological Saline; while groups B, C, and D (comprised ten (10) rats) were given 75 mg/kg, 150 mg/kg and 300 mg/kg of body weight of aluminum chloride respectively for 39 days. At day 40, the aluminum-treated groups were subdivided into sub-groups (B1, C1, D1) comprising of five (5) rats each, and 30 mg/ kg body weight of Riboceine were administered for twenty (20) days. Groups B, C and D remained on the normal dosage of aluminum chloride for three more weeks (59 days). Results: Andrological parameters (Sperm count, motility, morphology and testosterone) in the aluminum- treated Groups B and C showed no significant difference in their mean values when compared with their control counterparts, whereas there was a significant reduction in the andrological parameters in Group D rats when compared with the Control animals. Histoarchitecture of the testes “stain with H&E” of Group A, B and C rats appeared normal while Group D rats showed testicular damages with several abnormal seminiferous tubules with incomplete maturation of germinal cell layers and absence of spermatozoa in their lumen; Leydig cells appear hyperplastic. Group B1, C1 and D1 andrological and histological parameters appeared normal. Conclusion: Riboceine treatment significantly attenuates aluminum-induced testicular toxicity in male Sprague-Dawley in rats.en_US
dc.identifier.citationFalana B., Adeleke, O., Orenolu, M., Osinubi, A., & Oyewopo, A. (2017). Effect of D-ribose-L-cysteine on aluminum induced testicular damage in male Sprague-Dawley rats. JBRA Assisted Reproduction, 21(2):94-100. DOI: 10.5935/1518-0557.20170023.en_US
dc.identifier.otherdoi: 10.5935/1518-0557.20170023
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10385
dc.language.isoenen_US
dc.publisherJBRA Assisted Reproductionen_US
dc.relation.ispartofseries21;2
dc.subjectTestes, aluminum chloride, D-Ribose and L-Cysteine, sprague-dawley ratsen_US
dc.titleEffect of D-ribose-L-cysteine on aluminum induced testicular damage in male Sprague-Dawley ratsen_US
dc.typeArticleen_US
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