Methacrylated chitosan as a polymer with enhanced mucoadhesive properties for transmucosal drug delivery

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dc.contributor.authorKolawole, OM
dc.contributor.authorLau, WM
dc.contributor.authorKhutoryanskiy, VV
dc.date.accessioned2022-01-12T15:51:26Z
dc.date.available2022-01-12T15:51:26Z
dc.date.issued2018
dc.descriptionScholarly articlesen_US
dc.description.abstractChitosan is a cationic polysaccharide that exhibits mucoadhesive properties which allow it to adhere to mucosal tissues. In this work, we explored chemical modification of chitosan through its reaction with methacrylic anhydride to synthesise methacrylated derivative with the aim to improve its mucoadhesive properties. The reaction products were characterised using 1H NMR, FTIR and UV–Vis spectroscopy. 1H NMR and ninhydrin test were used to quantify the degree of methacrylation of chitosan. Turbidimetric analysis of the effect of pH on aqueous solubility of the polymers revealed that the highly methacrylated derivative remained turbid and its turbidity did not change from pH 3 to 9. However, solutions of native chitosan and its derivative with low methacrylation remained transparent at pH 6.5 and exhibited a rapid increase in turbidity at pH > 6.5. The mucoadhesive properties of chitosan and its methacrylated derivatives were evaluated using flow-through method combined with fluorescent microscopy with fluorescein sodium as a model drug. The retention of these polymers was evaluated on porcine bladder mucosa in vitro. The methacrylated derivatives exhibited greater ability to retain fluorescein sodium on the bladder mucosa compared to the parent chitosan. Toxicological studies using MTT assay with UMUC3 bladder cells show no significant differences in toxicity between chitosan and its methacrylated derivatives suggesting good biocompatibility of these novel mucoadhesive polymers.en_US
dc.identifier.citationKolawole OM, Lau WM, Khutoryanskiy VV (2018). Methacrylated chitosan as a polymer with enhanced mucoadhesive properties for transmucosal drug delivery. Int J Pharm 550(1-2), 123-129en_US
dc.identifier.otherdoi: 10.1016/j.ijpharm.2018.08.034
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/10191
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectChitosanen_US
dc.subjectMucoadhesiveen_US
dc.subjectMethacrylic anhydrideen_US
dc.subjectIntravesical drug deliveryen_US
dc.subjectUMUC3 cellen_US
dc.subjectToxicityen_US
dc.subjectBiological fluid Wash-out50en_US
dc.subjectResearch Subject Categories::PHARMACYen_US
dc.titleMethacrylated chitosan as a polymer with enhanced mucoadhesive properties for transmucosal drug deliveryen_US
dc.typeArticleen_US
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