Synthesis and Antimicrobial Activity of Schiff Bases derived from substituted Salicyladehyde with 2-aminophenol and 2-aminothiophenol
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Date
2013-01
Authors
Fashina, T.M.
Ejiah, F.N.
Dueke-Eze, C.U.
Idika, N.
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Scientific Research and Development
Abstract
Schiff bases of substituted salicylaldehydes namely 5-bromosalicylaldehyde and 5-nitrosalicyladehyde with 2- aminophenol and 2-aminothiophenol have been synthesized and characterized by IR, NMR and elemental analysis. All synthesized compounds were screened for their antimicrobial activity against some clinically important bacteria; Escherichia coli ATCC 25922, Pseudomonas aeruginosa ATCC 27853, Staphylococcus aureus ATCC25923, Enterococcus feacalis ATCC 29212 by Agar ditch method using N,N’-dimethylformamide (DMF) and 1,4-dioxane as solvents. Activity data shows a higher activity of the compounds in DMF with the bromo substituted imines more potent than the nitro substituted compound
Description
Staff publications
Keywords
Schiff base , 2-aminophenol , 2-aminothiophenol , Antimicrobial activity , Research Subject Categories::NATURAL SCIENCES::Chemistry
Citation
Fasina, T.M., Elijah, F.N., & Dueke-Eze, C.U., & Idika, N. (2013). Synthesis and Antimicrobial Activity of Schiff Bases Derived from Substituted Salicylaldehyde with 2-aminophenol and 2-aminothiophenol. Journal of Scientific Research and Development. Vol.14. 95-98pp.