Sexually transmitted infections in pregnancy - An update on Chlamydia trachomatis and Neisseria gonorrhoeae.

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dc.contributor.authorOlaleye, A.O.
dc.contributor.authorBabah, O.A.
dc.contributor.authorOsuagwu, C.S.
dc.contributor.authorOgunsola, F.T.
dc.contributor.authorAfolabi, B.B.
dc.date.accessioned2022-01-04T11:26:14Z
dc.date.available2022-01-04T11:26:14Z
dc.date.issued2020-12
dc.descriptionScholarly articlesen_US
dc.description.abstractRoutine screening for Chlamydia and gonococcal infection in pregnancy is not widespread, especially in low- and middle-income countries (LMICs), despite their potential adverse consequences on pregnancy outcome. We conducted a systematic literature search of three major databases to review current literature surrounding Chlamydia trachomatis and Neisseria gonorrhoeae infections in pregnancy. We discuss the epidemiology and burden of both infections, detection methods, potential adverse feto-maternal and infant outcomes and provide an overview of treatment options. A total of 67 articles met the inclusion criteria. The prevalence of C. trachomatis and N. gonorrhoeae across all trimesters ranged between 1.0%-36.8% and 0-14.2% worldwide, respectively. The most common diagnostic method is the Nucleic acid amplification test (NAAT). In pregnancy, chlamydia is associated with preterm birth, spontaneous miscarriage, stillbirth and neonatal conjunctivitis, while gonorrhoea is mainly associated with preterm birth and stillbirth. Amoxicillin, erythromycin and azithromycin showed similar efficacy in the treatment of chlamydia in pregnancy, while ceftriaxone and cefixime were effective in treating gonorrhoea in pregnancy. Being largely asymptomatic infections in women, we opine that detection strategies with locally appropriate tools should be combined with the syndromic approach in LMICs, where there is a high burden of disease.en_US
dc.identifier.citationOlaleye AO, Babah OA, Osuagwu CS, Ogunsola FT, Afolabi BB. Sexually transmitted infections in pregnancy - An update on Chlamydia trachomatis and Neisseria gonorrhoeae. Eur J Obstet Gynecol Reprod Biol. 2020 Dec;255:1-12. doi: 10.1016/j.ejogrb.2020.10.002. Epub 2020 Oct 8. PubMed PMID: 33059307.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9930
dc.language.isoenen_US
dc.publisherEur J Obstet Gynecol Reprod Biolen_US
dc.subjectChlamydiaen_US
dc.subjectGenital infectionsen_US
dc.subjectGonorrhoeaen_US
dc.subjectPregnancyen_US
dc.subjectScreeningen_US
dc.subjectSexually transmitted diseasesen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleSexually transmitted infections in pregnancy - An update on Chlamydia trachomatis and Neisseria gonorrhoeae.en_US
dc.typeArticleen_US
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