Allergenicity of dominant aeropollen in Nigeria: Part I

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dc.contributor.authorAdeniyi, Tiwalade Adeyemi
dc.contributor.authorAdeonipekun, Peter Adegbenga
dc.contributor.authorOlowokudejo, James Dele
dc.contributor.authorAkande, Idowu
dc.date.accessioned2019-09-16T12:38:21Z
dc.date.available2019-09-16T12:38:21Z
dc.date.issued2017-10
dc.description.abstractSeveral pollen grains have been studied in detail for purification and characterisation of allergenic components in the advanced countries; however, many are yet to be studied in the tropics, including Nigeria. To close this gap, four pollen grains (Poaceae – Cynodon dactylon, Panicum maximum; Cyperaceae – Cyperus rotundus and Mariscus alternifolius) found dominant in the air from previous aeropalynological studies in Nigeria were selected. The pollen grains were harvested from fresh anthers and their proteins were extracted, quantified, separated and subjected to Western-blot analysis. The allergenic proteins were also identified. While C. dactylon had the highest protein content (17.09 mg/mL), M. alternifolius had the lowest (11.19 mg/mL). Western-blot analysis showed that individuals were most susceptible to the 35 kDa protein of C. dactylon (76%). Furthermore, only C. dactylon proteins of 14.5 kDa and 35 kDa were identified with their exact matches in the ProFound database (Cyn d 12 and Cyn d 1 respectively), whereas the peptide sequences of eight protein bands were newly added to the database. Of these, the Profilin protein group (14 kDa) is common to all studied pollen grains – an indication of veritable immunotherapeutic potential. This study is the first in Nigeria to record allergenic proteins in these pollen grains and to create a foundation for the development of immunotherapy drugs for allergy treatment in the countryen_US
dc.identifier.citationAdeniyi, Tiwalade & Adeonipekun, Peter & Olowokudejo, James & Akande, Idowu. (2017). Allergenicity of dominant aeropollen in Nigeria: Part I. Current Allergy and Clinical Immunology. 30. 264-269.en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/5571
dc.language.isoenen_US
dc.publisherCurrent Allergy & Clinical Immunologyen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistry::Biochemistryen_US
dc.subjectallergenic proteinsen_US
dc.subjectimmunotherapyen_US
dc.subjectNigeriaen_US
dc.subjectpollen grainsen_US
dc.subjectWestern Bloten_US
dc.titleAllergenicity of dominant aeropollen in Nigeria: Part Ien_US
dc.typeArticleen_US
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