EFFECT OF BLACK TEA ON THE DISSOLUTION PROFILE OF LISINOPRIL TABLETS

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dc.contributor.authorBAMIRO, O.K
dc.contributor.authorAkinleye, M.O.
dc.contributor.authorOyetunde, O.O.
dc.date.accessioned2019-09-21T20:10:40Z
dc.date.available2019-09-21T20:10:40Z
dc.date.issued2013-02-06
dc.description.abstractObjective: The aim of the study is to determine the effect of Black tea on the dissolution profile of Lisinopril tablets. Method: In vitro dissolution of Lisinopril tablets was studied in the absence of black tea as a control media and in the presence of black tea as a test media at pH 1.2, 4.5 & 6.8 (to simulate gastro intestinal condition) using USP apparatus II at 50rpm. 12 units were used according to USP specification and sampling was done at 5, 10, 15, 30, 45 and 60 minutes. Analysis of Lisinopril was done using High Performance Liquid Chromatography- coupled with ultra-violent detector. Result: Results of the study showed that at pH 1.2, Black tea significantly decreased the dissolution of Lisinopril tablets (P = 0.0001). At pH 4.5 and 6.8 Black tea significantly increased the dissolution of Lisinopril tablets with (p = 0.004) and (p = 0.0007) respectively. Conclusion: Co- administration of Lisinopril tablets and black tea among patients could lead to unpredictable and unexpected clinical effect, therefore health care personnel should encourage patients to take medication with portable water from credible sources and to space the consumption of beverages and administration of oral medications.en_US
dc.identifier.citationOBAMIRO, OK, AKINLEYE, MO AND OYETUNDE OOEFFECT OF BLACK TEA ON THE DISSOLUTION PROFILE OF LISINOPRIL TABLETS (2013) International Journal of Pharmacy and Pharmaceutical Sciences, Vol 5, Suppl 1, 2013en_US
dc.identifier.issn0975-1491
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6011
dc.language.isoenen_US
dc.publisherAcademic Sciencesen_US
dc.subjectBlack Teaen_US
dc.subjectLisinoprilen_US
dc.subjectDissolutionen_US
dc.subjectCardiovascular diseaseen_US
dc.titleEFFECT OF BLACK TEA ON THE DISSOLUTION PROFILE OF LISINOPRIL TABLETSen_US
dc.typeArticleen_US
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