High Performance Liquid Chromatographic Analysis of Ten Brands of Pefloxacin Tablets Marketed in Mainland Area of Lagos.
| dc.contributor.author | Adepoju-Bello A.A. | |
| dc.contributor.author | Lawal K.B. | |
| dc.contributor.author | Ayoola G.A. | |
| dc.date.accessioned | 2021-12-30T21:27:03Z | |
| dc.date.available | 2021-12-30T21:27:03Z | |
| dc.date.issued | 2014 | |
| dc.description | Scholarly articles | en_US |
| dc.description.abstract | Pefloxacin belongs to the fluoroquinolone family which are highly potent and orally active broad spectrum antibacterial antibiotics developed from the original 1,8-naphthyridine urinary antibacterial agent, nalidixic acid. Counterfeiting of drugs is a major problem being faced today in the pharmaceutical sector and in the community. Such drugs lead to reduced efficacy of pharmacotherapy. The objective of this study is to assay the different brands of pefloxacin available in Lagos market, to ascertain the brands that are suitable for administration. Ten different brands of pefloxacin, selected from different localities within the mainland area of Lagos were subjected to the same official methods of analyses. The United States Pharmacopoeia (USP) and British Pharmacopoeia (BP) methods were adopted for the physicochemical tests and the high performance liquid chromatograghic method was developed for the quantitative assay. Our results showed that all the brands passed the physical tests. Some brands were found satisfactory in terms of the prescribed specification for percentage purity going by the BP (95%-105% of the labeled content). However nine brands out of ten assayed (90%) satisfied the USP specification (90%- 110%). Cognisance is taken of the fact that at both levels of percentage purity, on administration to humans, therapeutic concentrations are achieved easily and rapidly. The assay of drugs in the market regularly is paramount to ascertain the brands that are within the official standard for treatment. | en_US |
| dc.identifier.citation | J. Pharm. Sci. & Pharm. Pract Vol. 10 (1), January- March, 2014 | en_US |
| dc.identifier.issn | 11170816 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/9810 | |
| dc.language.iso | en | en_US |
| dc.publisher | J. Pharm. Sci. & Pharm. Pract. | en_US |
| dc.subject | Pefloxacin | en_US |
| dc.subject | Substandard drug | en_US |
| dc.subject | Fake drug | en_US |
| dc.subject | Fluoroquinolone Family | en_US |
| dc.subject | Research Subject Categories::PHARMACY::Pharmaceutical chemistry | en_US |
| dc.title | High Performance Liquid Chromatographic Analysis of Ten Brands of Pefloxacin Tablets Marketed in Mainland Area of Lagos. | en_US |
| dc.type | Article | en_US |