Comparative study of the effect of tocotrienols and -tocopherol on fasting serum lipid profiles in patients with mild hypercholesterolaemia: a preliminary report.
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Date
2007-04
Authors
Ajuluchukwu, J.N.
Okubadejo, N.U.
Mabayoje, M.
Ojini, F.I.
Okwudiafor, R.N.
Mbakwem, A.C.
Fasanmade, O.A.
Oke, D.A.
Journal Title
Journal ISSN
Volume Title
Publisher
National Postgraduate Medical College of Nigeria
Abstract
OBJECTIVES:
Hypercholesterolaemia is a risk factor for cardiovascular diseases. Tocotrienols reportedly possess hypocholesterolaemic activity. This study examined the effect of tocotrienols (T3) in TOCOVIDTM Suprabio TM on serum lipids. Patients and Methods :A randomised (2:1), open-label study of patients with mild hypercholesterolaemia (= 5.18mmol/L to <7.77mmol/L) and one additional cardiovascular risk factor was carried out. Subjects received either tocotrienols (as TOCOVIDTM Suprabio TM ) (n=28) or vitamin E (a-tocopherol) 500mg daily (n=16). Fasting lipids were compared at baseline and after 4 weeks therapy.
RESULTS:
Following 4 weeks therapy, mean +/- SD total cholesterol declined significantly in the tocotrienol group (from 6.10+/-0.66 to 5.47+/-1.16; P=0.02) compared to the a-tocopherol group (from 5.92+/-0.52 to 5.47+/-0.76; P>0.05). Mean LDL-C levels (mmol/L) were also significantly reduced in the tocotrienol group (3.82+/-0.85 to 3.24+/-1.26; P=0.04), but not in those on a-tocopherol (3.84+/-0.75 to 3.28+/-0.94; P>0.05). There were no significant changes in HDL-C and triglycerides in both groups. The tocotrienol group experienced a net decline in TG (7.1+/-31.4 %; P>0.05) while the a-tocopherol group had a net increase at week 4 (38.6+/-61.7%; P>0.05).
CONCLUSION:
The study adds to existing evidence of the favourable effect of tocotrienols on total cholesterol and LDL-C. However, the results need further evaluation.
Description
Staff publications
Keywords
Hypercholesterolemia , Dyslipidemia , Vitamin E , Tocotrienols , Treatment , Research Subject Categories::MEDICINE
Citation
Ajuluchukwu JN, Okubadejo NU, Mabayoje M, Ojini FI, Okwudiafor RN, Mbakwem AC, Fasanmade OA, Oke DA. Comparative study of the effect of tocotrienols and -tocopherol on fasting serum lipid profiles in patients with mild hypercholesterolaemia: a preliminary report. Niger Postgrad Med J. 2007 Mar;14(1):30-3.