Some Pharmacopoeial and Diluent-Binder Properties of α-Cellulose derived from Maize Cob in Selected Tablet Formulations
| dc.contributor.author | Azubuike, C.P. | |
| dc.contributor.author | Okhamafe, A.O. | |
| dc.contributor.author | Falodun, A. | |
| dc.date.accessioned | 2020-02-24T09:31:14Z | |
| dc.date.available | 2020-02-24T09:31:14Z | |
| dc.date.issued | 2011 | |
| dc.description | Staff publications | en_US |
| dc.description.abstract | As part of continuing efforts to develop low-cost pharmaceutical grade cellulose, α-cellulose (MC) was extracted from an agricultural waste (de-grained maize cob) and characterized as a tablet diluent using a commercial brand of microcrystalline cellulose (MCC) and a mixture of lactose and starch (LS) as reference standards. The α-cellulose met the pharmacopoeial specifications (for Powdered Cellulose B.P.), including pH - 6.5 ± 0.5; loss on drying - 6.0%; residue on ignition - 0.03%; and water-soluble substances - 0.9%. Presence of organic impurities and starch was not found. MC compared well with MCC and LS in terms of bulk density (0.36g/cm3) and true density (1.59g/cm3). MC, MCC and LS were individually evaluated as tablet diluents for some commonly used drugs, namely, folic acid, chloroquine and vitamin B complex. The tablets were prepared by pre-compression. Based on the tablet parameters examined, (including tensile strength, disintegration time and dissolution data), MC-based tablets compared well with MCC- and LS-based tablets. MC formulations were highly compressible (no binding agent was needed) and yielded folic acid and vitamin B complex tablets that were self-lubricating (no lubricant was needed). However, folic acid-MC and folic acid-MCC tablets, unlike folic-LS tablets, failed to disintegrate within 15 min (BP limit). Chloroquine tablets produced with the three diluents passed all the pharmacopoeial tests (BP) but a lubricant was included in the formulations to eliminate sticking. The findings from this work confirm the tablet diluent-binder potentials of α-cellulose derived from maize cob in tablet produced by the pre-compression method. | en_US |
| dc.identifier.citation | Azubuike, C.P., Okhamafe, A.O. and Falodun, A., (2011). Some pharmacopoeial and diluent-binder properties of maize cob-derived from α-cellulose in selected tablet formulations. J. Chem. Pharm. Res, 3(3), pp.481-488. | en_US |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/7813 | |
| dc.language.iso | en | en_US |
| dc.relation.ispartofseries | J. Chem. Pharm. Res;Vol.3(3) | |
| dc.subject | α-cellulose | en_US |
| dc.subject | pharmacopoeial characterization | en_US |
| dc.subject | physicochemical properties | en_US |
| dc.subject | diluent | en_US |
| dc.subject | Research Subject Categories::PHARMACY | en_US |
| dc.title | Some Pharmacopoeial and Diluent-Binder Properties of α-Cellulose derived from Maize Cob in Selected Tablet Formulations | en_US |
| dc.type | Article | en_US |