Effect of YoYo bitters on the dissolution of lisinopril tablets
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Date
2015-02
Authors
Ayandokun, A.O
Oyetunde, O.O.
Akinleye, M.O.
Journal Title
Journal ISSN
Volume Title
Publisher
Dissolution Technologies
Abstract
Lisinopril is an angiotensin converting enzyme inhibitor (ACEI), e!ective in lowering blood pressure in all grades of
essential and renovascular hypertension. YoYo Cleanser Bitters is a liquid oral herbal medication reported to be bene"cial
in the management of illnesses such as diabetes, hypertension, and obesity, and for the general well-being of the body. The
use of herbal bitters like YoYo Bitters is high in Nigeria, especially among patients with chronic illnesses like hypertension
and diabetes. The aim of the study was to determine the e!ect of YoYo Bitters on the dissolution pro"le of lisinopril tablets.
In vitro dissolution of lisinopril tablets was studied in the presence and absence of YoYo Bitters at pH 1.2, 4.5, and
6.8 using USP Apparatus 2 at 50 rpm. Twelve tablets from the same batch were used according to USP speci"cation,
and sampling was done at 5, 10, 15, 30, 45, and 60 min. Analysis of lisinopril was done using high performance liquid
chromatography (HPLC) coupled with a UV detector.
Results of the study show that at pH 1.2, the dissolution of lisinopril tablets increased signi"cantly in the presence of
YoYo Bitters (p = 0.0015). At pH 4.5, there was no statistically signi"cant di!erence between the dissolution of lisinopril
tablets with and without YoYo Bitters (p = 0.1232). At pH 6.8, the dissolution of lisinopril tablets decreased signi"cantly in the presence of YoYo Bitters (p = 0.0140). Therefore, coadministration of YoYo Bitters and lisinopril tablets could lead to alteration in the dissolution of lisinopril and consequently change its bioavailability.
Description
Keywords
Dissolution , Lisinopril tablets , YOYO Bitters
Citation
Olubunmi, A. Ayandokun, O. Oyetunde Olubukola, and O. Akinleye Moshood. "Effect of YoYo bitters on the dissolution of lisinopril tablets." diabetes 10 (2015): 11.