Serum Uric Acid Level and its Relationship to Non-Motor Symptomatology in Parkinson’s Disease
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Date
2018-04-10
Authors
Odeniyi, O.
Okubadejo, N.U.
Ojo, O.O.
Danesi, M.A.
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer
Abstract
Objective: To determine the relationship between serum uric acid level and non-motor
symptoms using the PD specific non-motor symptoms in Nigerian patients with Parkinson’s
disease.
Background: Uric acid in low levels have been associated with rapid progression of motor
symptoms of Parkinson disease, increased disease severity and increased frequency of non-motor
symptoms. There is a paucity of studies on serum uric acid and non-motor symptoms in
Parkinson’s disease. This study was conceptualized to determine the relationship between serum
uric acid levels and the frequency of non-motor symptoms especially in Parkinson’s disease
patient of African descent.
Design/Methods: This was a 6-month analytical cross-sectional study recruiting 70 patients with
Parkinson’s disease and 140 age and gender matched controls. Parkinson’s disease patients who
met the inclusion criteria for the study were recruited consecutively from the Movement
Disorders Clinic of the Lagos University Teaching Hospital. Healthy controls who met the
inclusion criteria for controls were also recruited from volunteers. The non-motor symptoms
were assessed with the Non-Motor Questionnaire. Serum uric acid measurement was
determined on 5 mls of non-fasting venous blood drawn from each participant from a peripheral
vein.
Results: Mean serum uric acid in PD (2.43 ± 0.75 mg/dl) was significantly lower than in controls
(3.73 ± 1.09 mg/dl) (p <0.001). The non-motor symptoms that showed an independent
correlation with serum uric acid using multivariate logistic regression analysis were loss of
taste/smell with odds ratio of 0.411 (95% confidence interval (CI) of 0.196 – 0.863) and memory
impairment with odd ratio of 0.466 (95% confidence interval of 0.229 – 0.948).
Conclusions: Low serum uric acid showed that serum uric acid is low in patients with
Parkinson’s disease and associated with increased frequency of non-motor symptoms. It could
predict the occurrence of memory impairment and loss of taste/smell.
Description
Keywords
Parkinson disease , Biomarkers , Uric acid , Non motor symptoms
Citation
Odeniyi O, Okubadejo N, Ojo O, Danesi M. Serum Uric Acid Level and its Relationship to Non-Motor Symptomatology in Parkinson’s Disease. Neurology. 2018; 90 (15 Supplement): P1.048.