The prevalence and genetics of Parkinson's disease in sub-Saharan Africans

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dc.contributor.authorBlanckenberg, J.
dc.contributor.authorBardien, S.
dc.contributor.authorGlanzmann, B.
dc.contributor.authorOkubadejo, N.U.
dc.contributor.authorCarr, J.A.
dc.date.accessioned2019-11-01T14:15:46Z
dc.date.available2019-11-01T14:15:46Z
dc.date.issued2013-12-15
dc.descriptionStaff publicationsen_US
dc.description.abstractParkinson's disease (PD) is under-studied in Black Sub-Saharan African (SSA) populations. To date, there have been only six prevalence and no incidence studies. The crude prevalence of PD in SSA varies from 7 to 20 per 100,000, which is appreciably lower than in Caucasian populations. There are a limited number of published studies (nine) on the genetic factors associated with PD in SSA populations. Mutations have been reported in the parkin gene, and are restricted to only three patients (two Black South Africans and one Zambian). No mutations have been identified in the LRRK2, SNCA, PINK, or DJ-1 genes. Given the unique ancestry of SSA populations, their inclusion in genetic studies may provide a substantial contribution to the identification of novel genetic factors and genetic-environmental interactions underlying this disorder. More initiatives are needed to drive further research on PD in these populations and to facilitate collaborative projects across Africa.en_US
dc.identifier.citationBlanckenberg J, Bardien S, Glanzmann B, Okubadejo NU, Carr JA. The prevalence and genetics of Parkinson's disease in sub-Saharan Africans. J Neurol Sci. 2013 Dec 15;335(1-2):22-5.en_US
dc.identifier.otherdoi: 10.1016/j.jns.2013.09.010.
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6659
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectEpidemiologyen_US
dc.subjectEtiologyen_US
dc.subjectGenetic studiesen_US
dc.subjectParkinson's diseaseen_US
dc.subjectPrevalenceen_US
dc.subjectSub-Saharan Africaen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleThe prevalence and genetics of Parkinson's disease in sub-Saharan Africansen_US
dc.typeArticleen_US
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