Prevalence of and Risk Factors for Lipoatrophy in Patients with HIV Infection in Nigeria

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dc.contributor.authorIwuala, S.
dc.contributor.authorLesi, O.A.
dc.contributor.authorFasanmade, O.
dc.contributor.authorSabir, A.A.
dc.contributor.authorOlamoyegun, M.A.
dc.contributor.authorOkany, C.C.
dc.date.accessioned2019-11-08T15:28:24Z
dc.date.available2019-11-08T15:28:24Z
dc.date.issued2015-03
dc.descriptionStaff publicationsen_US
dc.description.abstractBACKGROUND: Although the association between lipoatrophy and highly active antiretroviral therapy (HAART) is well known, other nondrug factors may be associated with lipoatrophy in people living with HIV/AIDS (PLWHA). There are no reports of lipoatrophy from Nigeria, a country with the second largest number of PLWHA. We aimed to determine the prevalence, characteristics, and factors associated with lipoatrophy in a cohort of patients attending the HIV clinic in Lagos University Teaching Hospital, Nigeria. METHODS: Two hundred and eighty-eight patients with HIV infection were recruited for the study. The study protocol involved administration of a questionnaire, targeted physical examination (including anthropometric indices and skin fold thickness), and bioelectrical impedance analysis measurements. Lipoatrophy was defined clinically. RESULTS: Lipoatrophy was present in 75 (26.0%) persons. It was associated with lower body circumferences, skin fold thicknesses, and lower % body fat with preservation of skeletal muscle mass (all P < 0.05). Male gender and HAART use were the factors associated with lipoatrophy on multivariate analysis (P < 0.05). CONCLUSION: Lipoatrophy is frequently encountered in patients with HIV infection in Nigeria, with HAART use conferring an added factor in its development. There is need for more physician and patient awareness of this conditionen_US
dc.identifier.citationIwuala SO, Lesi OA, Fasanmade OA, Sabir AA, Olamoyegun MA, Okany CC. Prevalence of and Risk Factors for Lipoatrophy in Patients with HIV Infection in Nigeria. AIDS Res Treat. 2015;2015:402638.en_US
dc.identifier.issn20901240, 20901259
dc.identifier.otherdoi: 10.1155/2015/402638.
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6791
dc.language.isoenen_US
dc.publisherHindawi Publishing Corporationen_US
dc.subjectHIV/AIDSen_US
dc.subjectUniversity teaching hospitalen_US
dc.subjectPatientsen_US
dc.subjectInfectionsen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titlePrevalence of and Risk Factors for Lipoatrophy in Patients with HIV Infection in Nigeriaen_US
dc.typeArticleen_US
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