Hypopituitarism and patterns of hormonal replacement in an endocrinology clinic
| dc.contributor.author | Udo, C | |
| dc.contributor.author | Olopade, O.B | |
| dc.contributor.author | Odeniyi, I.A | |
| dc.contributor.author | Fasanmade, O.A | |
| dc.date.accessioned | 2021-12-28T00:03:53Z | |
| dc.date.available | 2021-12-28T00:03:53Z | |
| dc.date.issued | 2019-11 | |
| dc.description | Conference papers | en_US |
| dc.description.abstract | Introduction: Hypopituitarism refers to a deficiency of one or more of the pituitary hormones. Hypopituitarism is often partial, thus replacement is individualized. Hormonal replacement improves the quality of life in these patients. Objective: To describe the demographic characteristics and patterns of hormonal replacement in patients with hypopituitarism attending the Endocrinology clinic of a tertiary hospital in Lagos, Nigeria. Methods: We reviewed charts of patients with hypopituitarism attending the Endocrinology clinic of LUTH over a two-year period. Information obtained from the charts included sex, age, aetiology of hypopituitarism, and replacement therapy. Results were presented as averages and percentages. Results: There were 22 patients, 12(55%) males, and 10(45%) females. The mean age was 43±11.85 years. 18(81.8%) had macroadenomas; 4(18.2%) microadenomas. The majority (16) of the patients with macroadenoma had undergone adenectomy, compared with 1 among those with microadenoma. Of the 22, 19(86.4%) were on hormonal therapy. The most frequently replaced hormone was Cortisol (14 patients); 12 on oral hydrocortisone, an average dose of 15 mg daily, and 2 on prednisolone tablets, 5 mg daily. Hyperprolactinaemia occurred in 8 patients, 7 were on Tabs Cabergoline, average doses 0.25–0.5 mg twice weekly; 1 was on Tabs Bromocriptine. Thyroxine replacement was required in 6 patients, average dose 50 mcg daily. 2 patients required Desmopressin replacement. Only 1 male was on replacement with human chorionic gonadotropin. Overall, 11 (50%) required replacement with ≥2 hormones. Conclusion: The majority of patients reviewed had previous adenectomy, underscoring the necessity of endocrine assessment, post-surgery. Hormone replacement is usually life-long. Cortisol was the most frequently replaced. It appears there is a gap in screening for and replacing growth hormone in the clinic. | en_US |
| dc.identifier.citation | Udo C, Olopade O, Odeniyi I, Fasanmade O. Hypopituitarism and patterns of hormonal replacement in an endocrinology clinic. Endocrine Abstracts. (2019) 65 P316 | DOI: 10.1530/endoabs.65.P316 | en_US |
| dc.identifier.issn | 1479-6848 (online) | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/9801 | |
| dc.language.iso | en | en_US |
| dc.publisher | Bioscientifica | en_US |
| dc.subject | Hypopituitarismpy | en_US |
| dc.subject | Hormone replacement therapy | en_US |
| dc.subject | Patients | en_US |
| dc.subject | Endocrinology clinic | en_US |
| dc.subject | Research Subject Categories::MEDICINE | en_US |
| dc.title | Hypopituitarism and patterns of hormonal replacement in an endocrinology clinic | en_US |