The Physicochemical Equivalence of Eight Brands of Amlodipine Tablets in Lagos, Nigeria

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dc.contributor.authorOlayemi, S.O.
dc.contributor.authorAkinleye, M.O.
dc.contributor.authorAwodele, E.O.
dc.contributor.authorIdris, O.
dc.contributor.authorOladimeji-salami, J.
dc.date.accessioned2019-09-30T14:51:20Z
dc.date.available2019-09-30T14:51:20Z
dc.date.issued2012-09
dc.descriptionStaff publicationsen_US
dc.description.abstractBACKGROUND: Amlodipine is a dihydropyridine calcium channel antagonist that is useful in the treatment of hypertension and angina pectoris. In addition to the innovator brand of this molecule, several generic brands are marketed in Nigeria. OBJECTIVE: To evaluate the physicochemical equivalence of eight brands of amlodipine tablets marketed in Lagos, Nigeria. METHODS: Physicochemical properties such as identity, weight uniformity, friability, hardness test, disintegration test, dissolution test and assay of active ingredients were performed using the methods described in the British and the United States Pharmacopoeia. Ultra-violetspectrophotometric and High performance liquid chromatographic methods were used for assay of the labelled amount of amlodipine in the products. RESULTS: All the products passed weight uniformity and disintegration tests. Only one brand failed the friability test. Two brands had mean crushing strength less than 4kg/cm2; while only 4 brands passed dissolution test by releasing >75% of the labelled amlodipine within 45 minutes. One brand failed both assay and dissolution tests by returning less than official specifications in the general monograph for conventional tablets. In all, four of the eight sample products analyzed passed all the tests. These can be said to be physicochemically equivalent and may be clinically interchangeable or substituted. CONCLUSION: This study further highlights the concerns over the quality of drug products marketed in a developing country.en_US
dc.identifier.citationOlayemi, S.O [Et...al]. (2012). The Physicochemical Equivalence of Eight Brands of Amlodipine Tablets in Lagos, Nigeria. West African Journal of Medicine Vol. 31(3).en_US
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/6232
dc.language.isoenen_US
dc.publisherWest college of medicineen_US
dc.relation.ispartofseriesWest African Journal of Medicine;Vol.31
dc.subjectPhysicochemicalen_US
dc.subjectequivalenceen_US
dc.subjectamlodipine,en_US
dc.subjecttabletsen_US
dc.subjectResearch Subject Categories::NATURAL SCIENCES::Chemistryen_US
dc.titleThe Physicochemical Equivalence of Eight Brands of Amlodipine Tablets in Lagos, Nigeriaen_US
dc.typeArticleen_US
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