MICROWAVE-ASSISTED SOLVENT-FREE ARYLATION OF AMINO ACIDS WITH HALOGENOBENZENES
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Date
2018-06-21
Authors
Sowole, M.A.
Adebisi, A.B.
Olasupo, I.A.
Izunobi, J.U.
Familoni, O.B.
Journal Title
Journal ISSN
Volume Title
Publisher
journals.chemsociety.org.ng
Abstract
The solventless microwave-assisted arylation and heteroarylation of different aliphatic and cyclic amino acids 2a–e were carried out on activated, substituted o-nitrohalogenobenzenes 1a–h and 2-chloro-3-nitropyridine 1i, in the presence of potassium carbonate and potassium fluoride for 0.5 h at 70 W, to give substituted N-(o-nitrophenyl)amino-2-carboxylic acid 3–16 and N-(m-nitropyridyl)amino-2-carboxylic acid 17–18 adducts in yields ranging from 5–98% .
Description
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry , amino acids , arylation , halogenobenzenes , microwave synthesis
Citation
Sowole, M. A., Adebisi, A. B., Olasupo, I. A., Izunobi, J. U., & Familoni, O. B. (2018). Microwave-Assisted Solvent-Free Arylation of Amino acids with Halogenobenzenes. Journal of Chemical Society of Nigeria, 43(3).