Ivermectin shows clinical benefits in mild to moderate COVID-19: A randomised controlled double-blind dose-response study in Lagos.
| dc.contributor.author | Babalola, O.E. | |
| dc.contributor.author | Bode, C.O. | |
| dc.contributor.author | Ajayi, A.A. | |
| dc.contributor.author | Alakaloko, F.M. | |
| dc.contributor.author | Akase, I.E. | |
| dc.contributor.author | Otrofanowei, E. | |
| dc.contributor.author | Salu, O.B. | |
| dc.contributor.author | Adeyemo, W.L. | |
| dc.contributor.author | Ademuyiwa, A.O. | |
| dc.contributor.author | Omilabu, S. | |
| dc.date.accessioned | 2021-02-25T11:47:47Z | |
| dc.date.available | 2021-02-25T11:47:47Z | |
| dc.date.issued | 2021-02-18 | |
| dc.description | Scholarly articles | en_US |
| dc.description.abstract | Introduction In vitro studies have shown the efficacy of Ivermectin (IV) to inhibit the SARS - CoV- 2 viral replication, but questions remained as to In-vivo applications. We set out to explore the efficacy and safety of Ivermectin in persons infected with COVID19. Methods We conducted a translational proof of concept (PoC) randomized, double blind placebo controlled, dose response, parallel group study of IV efficacy in RT - PCR proven COVID 19 positive patients. 62 patients were randomized to 3 treatment groups. (A) IV 6mg regime, (B)IV 12 mg regime (given Q84hrs for 2weeks) (C, control) Lopinavir/Ritonavir. All groups plus standard of Care. Results The Days to COVID negativity [DTN] was significantly and dose dependently reduced by IV (p = 0.0066). The DTN for Control were, = 9.1+/-5.2, for A 6.0 +/- 2.9, and for B 4.6 +/-3.2 . 2 Way repeated measures ANOVA of ranked COVID 19 +/- scores at 0, 84, 168, 232 hours showed a significant IV treatment effect (p = 0.035) and time effect (p < 0.0001). IV also tended to increase SPO2% compared to controls, p = 0.073, 95% CI - 0.39 to 2.59 and increased platelet count compared to C (p = 0.037) 95%CI 5.55 - 162.55 × 103/ml. The platelet count increase was inversely correlated to DTN (r = -0.52, p = 0.005). No SAE was reported. Conclusions 12 mg IV regime may have superior efficacy. IV should be considered for use in clinical management of SARS-Cov-2, and may find applications in community prophylaxis in high-risk areas. | en_US |
| dc.identifier.citation | Babalola OE, Bode CO, Ajayi AA, Alakaloko FM, Akase IE, Otrofanowei E, Salu OB, Adeyemo WL, Ademuyiwa AO, Omilabu S. Ivermectin shows clinical benefits in mild to moderate COVID-19: A randomised controlled double-blind dose-response study in Lagos. QJM 2021. doi: 10.1093/qjmed/hcab035. | en_US |
| dc.identifier.other | doi.org/10.1093/qjmed/hcab035 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/9183 | |
| dc.language.iso | en | en_US |
| dc.publisher | Oxford Academics | en_US |
| dc.subject | Covid-19 | en_US |
| dc.subject | Virus | en_US |
| dc.subject | Treatment | en_US |
| dc.subject | Patients | en_US |
| dc.subject | Research Subject Categories::ODONTOLOGY | en_US |
| dc.title | Ivermectin shows clinical benefits in mild to moderate COVID-19: A randomised controlled double-blind dose-response study in Lagos. | en_US |
| dc.type | Article | en_US |