Economic Route to sodium-containing silicate bioactive glass scaffold.
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Date
2012
Authors
Essien, E.R.
Shaibu, R.O.
Olasupo, I.A.
Adams, L.A.
Oki, A.
Journal Title
Journal ISSN
Volume Title
Publisher
SCIRP
Abstract
Tetraethyl orthosilicate (TEOS) and trimethyl orthosilicate (TMOS) alkoxysilanes are expensive common precursors for silicate-based solgelderived bioactive glasses. Facile approaches involving low cost substitutes are a necessity
for bioactive glass implants in bone regeneration therapy. Quaternary SiO2-Na2O-CaO-P2O5 bioactive glass was prepared by the sol-gel method from locally sourced sand as precursor. The monolith glass material obtained was subjected to immersion studies in simulated body fluid (SBF) for 21 days. The surface morphology and composition of the glass before and after immersion in SBF was studied using SEM-EDX, while pH analysis was used to monitor changes
on the glass surface in SBF solution. FTIR was used to confirm apatite formation on the material. Results showed that the concentration of Ca, P and C increased on the surface of the glass sample as immersion time increased, which was
attributed to the formation of carbonated hydroxyapatite (HCA). The material shows ability to bond to bone making it a promising scaffold material for bone repair.
Description
Staff Publications
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Inorganic chemistry::Bio-inorganic chemistry , Tetraethyl orthosilicate , trimethyl orthosilicate , Alkoxysilanes , Ph analysis
Citation
Essien, E. R., [Et...al] (2012). Economic route to sodium-containing silicate bioactive glass scaffold. Open Journal of Regenerative Medicine, Vol.1(03), 33p.