Accuracy of urine dipsticks, 2-h and 12-h urine collections for protein measurement as compared with the 24-h collection
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Date
2008
Authors
Abebe, J
Eigbefoh, J
Isabu, P
Okogbenin, S
Eifediyi, R
Okusanya, B
Journal Title
Journal ISSN
Volume Title
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Abstract
Summary
The presence of protein in hypertensive disorders of pregnancy is a sign of a worsening condition and thus requires early
intervention to prevent adverse consequences. Accurate assessment of proteinuria in patients with pre-eclampsia will ensure prompt and timely intervention to reduce or prevent the maternal and perinatal morbidity and mortality associated with preeclampsia.
This study compared the reliability and validity of the more rapid diagnostic tests, such as the dipstick, 2-h and 12-
h protein estimations with the 24-h protein. The result of the dipstick, 2-h and 12-h urine were also compared with the 24-h urine results using confidence interval (CI) for proportions with a value of p50.05 considered significant (CI 95%). When compared with the gold standard, there was a high degree of correlation between the 2-h (p 0.244, CI 95%) and 12-h (p50.0255, CI 95%) with the 24-h sample in the quantification of proteinuria in women with pre-eclampsia. The most sensitive and specific test was the 12-h protein estimation, (89%) and (93%), respectively. The least sensitive and specific test was the dipstick test; (81%) and (47%), respectively. The 12-h protein estimation test had the highest positive predictive value (84%). The 12-h protein test also had the lowest false positive rate (12%) and false negative rates (11%), respectively. The most accurate test was the 12-h protein estimation (88%). The dipstick tests were however much cheaper and the results were faster. It is recommended that routine rapid quantisation of proteinuria in patients with pre-eclampsia be done using either the 2-h or 12-h urine sample.
Description
Scholarly article
Keywords
Pre-eclampsia, proteinuria, diagnosis, 24-h urine, urine dipstick , Pre-eclampsia , proteinuria , 24-h urine , urine dipstick , diagnosis , Research Subject Categories::MEDICINE::Surgery::Obstetrics and women's diseases
Citation
Abebe J, Eigbefoh J, Isabu P, Okogbenin S, Eifediyi R, Okusanya B. Accuracy of urine dipsticks, 2-h and 12-h urine collections for protein measurement as compared with the 24-h collection. J Obst Gynaecol 2008; 28(5):496-500