A genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African population

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dc.contributor.authorAdeyemo, A.A
dc.contributor.authorJohnson, T
dc.contributor.authorAcheampong, J
dc.contributor.authorOli, J
dc.contributor.authorOkafor, G
dc.contributor.authorAmoah, A
dc.contributor.authorOwusu, S
dc.contributor.authorAgyenim-Boateng, K
dc.contributor.authorEghan, B.A Jr
dc.contributor.authorAbbiyesuku, F
dc.contributor.authorFasanmade, O
dc.contributor.authorRufus, T
dc.contributor.authorDoumatey, A
dc.contributor.authorChen, G
dc.contributor.authorZhou, J
dc.contributor.authorChen, Y
dc.contributor.authorFubert-Harris, P
dc.contributor.authorDunston, G
dc.contributor.authorCollins, F
dc.contributor.authorRotimi, C
dc.date.accessioned2019-12-13T14:17:18Z
dc.date.available2019-12-13T14:17:18Z
dc.date.issued2005
dc.descriptionStaff publicationsen_US
dc.description.abstractLipid abnormalities are strongly linked with coronary heart disease and are common in type 2 diabetes. However, little is known about the genetic determinants of serum lipids in African populations. An autosomal genome scan was performed for linkage to five plasma lipid phenotypes (total cholesterol, triglycerides (TG), HDL-cholesterol (HDL-C), LDL-cholesterol (LDL-C) and VLDL-cholesterol (VLDL-C)) in the Africa–America Diabetes Mellitus (AADM) study. Two hundred and ninety-five affected sibling pairs with type 2 diabetes mellitus enrolled from Ghana and Nigeria were genotyped for 390 microsatellite markers with an average inter-marker distance of 9 cM. Multipoint variance components linkage analysis showed that HDL-C had a LOD score of 4.34 near marker D7S3061 and 3.00 near marker D7S513. Some clustering of linkage evidence to several lipid phenotypes was observed on chromosomes 5 (LDL-C, total cholesterol, VLDL-C), chromosome 7 (HDL-C, TG) and chromosome 19 (total cholesterol, LDL-C, TG). Principal component analysis of the five phenotypes yielded two factors, one (TG, HDL-C and VLDL) of which was linked to QTLs on chromosomes 2, 5 and 7, while the other (total cholesterol and LDL-C) was linked to a different set of QTLs on chromosomes 2, 5 and 18. Several of these regions have been reported to be linked to lipids in other studies. Follow up investigations are warranted in view of the central role serum lipids play in the aetiopathogenesis of cardiovascular disease.en_US
dc.identifier.citationAdeyemo AA, Johnson T, Acheampong J, Oli J, Okafor G, Amoah A, Owusu S, Agyenim-Boateng K, Eghan BA Jr, Abbiyesuku F, Fasanmade O, Rufus T, Doumatey A, Chen G, Zhou J, Chen Y, Fubert-Harris P, Dunston G, Collins F, Rotimi C. A genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African population. Atherosclerosis 2005; 181: 389–397en_US
dc.identifier.issn00219150
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7107
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.subjectGenome scanen_US
dc.subjectLipidsen_US
dc.subjectCholesterolen_US
dc.subjectType 2 diabetesen_US
dc.subjectAfricaen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleA genome wide quantitative trait linkage analysis for serum lipids in type 2 diabetes in an African populationen_US
dc.typeArticleen_US
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