Assay of Dosage Forms of Amodiaquine.
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Date
1997
Authors
Adepoju-Bello A.A.
Ayim J.S.K.
Journal Title
Journal ISSN
Volume Title
Publisher
J. Pharmaceut. Sci. & Pharm. Prac.
Abstract
A search through the literature of Amodiaquine has been done as well as a survey of methods of its assay.
UV/Visible spectrophotometric method is used for the assay of dosage forms of Amodiaquine using A (1%, 1 cm) at wavelength of absorption 342 nm. For high accuracy the differences in the absorbance of the standard and test solution must not exceed 10%.
This method was used as a standard method using A (1%, 1cm), 1 x 1 assay and calibration curve methods at wavelength of absorption 342 nm. It gave good reproducible and reliable results for all the dosage forms.
The gravimetric method was also used for the assay of the dosage forms of amodiaquine but the results were not reproducible and hence not reliable.
A potentiometric/lndicator direct titration method was developed and was used for amodiaquine tablet using water as the solvent, phenolphthalein or thymolphthalein as indicator and 0.2M sodium hydroxide as titrant. This method gave a reproducible and reliable result, also, the method is simple, precise and no sophisticated instrument is required.
For the syrup dosage form the potentiometric titration method does not give a reliable result because the excipients appear to affect the method.
Description
Scholarly articles
Keywords
Amodiaquine , Potentiometric titration , UV spectrophotometry , Gravimetry , Research Subject Categories::PHARMACY::Pharmaceutical chemistry
Citation
Adepoju-Bello AA and Ayim JSK (1997). Assay of Dosage Forms of Amodiaquine. J. Pharmaceut. Sci. & Pharm. Prac. 3: 25-28.