Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease): Report of a Case in a Nigerian Teaching Hospital.
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Date
2011-01-01
Authors
Ajayi, O.F.
Effiom, O.A.
Adeyemo, W.L.
Gbotolorun, O.M.
Akinshipo, W.
Journal Title
Journal ISSN
Volume Title
Publisher
Nig Dent J
Abstract
Sinus histiocytosis with massive lymphadenopathy (SHML) is a rare, benign disease of unknown aetiology. This disease typically presents with massive, painless cervical lymphadenopathy but may occur in a wide variety of extranodal sites. This report describes a 43-year old man with a left submandibular swelling and left lateral cervical lymphadenopathy clinically suggestive of a malignancy. Initial cytological examination of a fine needle aspirate specimen taken from the mass suggested a chronic granulomatous inflammatory lesion. A definitive diagnosis of SHML was however made only after excisional biopsy of the lesion. The patient was followed up for 6 months and no recurrence of the lesion was observed. SHML may be considered a rare lesion among Nigerians. Knowledge of its clinical presentation with understanding of the differentials diagnosis is important to avoid unnecessary intervention. The diagnosis can be made from FNAC, histopathology and immune-histochemistry. There is no ideal protocol for the treatment. Follow-up is however necessary to detect relapses.
Description
Staff publication
Keywords
Sinus histiocytosis , Research Subject Categories::ODONTOLOGY
Citation
Ajayi OF, Effiom OA, Adeyemo WL, Gbotolorun OM, Akinshipo W. Sinus Histiocytosis with Massive Lymphadenopathy (Rosai-Dorfman Disease): Report of a Case in a Nigerian Teaching Hospital. Nig Dent J 2011;19:32-35.