Synthesis, electronic spectra and inhibitory study of some salicylaldehyde Schiff bases of 2-aminopyridine
| dc.contributor.author | Dueke-Eze, C.U. | |
| dc.contributor.author | Fasina, T.M. | |
| dc.contributor.author | Idika, N. | |
| dc.date.accessioned | 2019-08-26T14:30:30Z | |
| dc.date.available | 2019-08-26T14:30:30Z | |
| dc.date.issued | 2011-02 | |
| dc.description.abstract | A series of Schiff bases namely N-(2-hydroxylbenzylidene)pyridin-2-amine (I), N-(5-nitro-2-hydroxylbenzylidene)pyridin-2-amine (II), N-(5-bromo-2-hydroxylbenzylidene)pyridin-2-amine (III) and N-(5-methoxy-2-hydroxylbenzylidene)pyridin-2-amine (IV) derived from 2-aminopyridine and substituted benzyaldehydes are reported and characterized by IR, 1HNMR and elemental analysis. The electronic absorption spectra of the compounds were studied in ethanol, N, N- dimethylformamide (DMF) and 1, 4-dioxane. The observed absorption bands were assigned to corresponding electronic transitions. A band above 400 nm obtained in II reveals keto-enol tautomerisim in DMF. In vitro screening of the compounds on Staphylococcus aureus ATCC 25923, Enterococcus feacalis ATCC 29212, Pseudomonas aeruginosa ATCC 27853 and Escherichia coli ATCC 25922 in N, N- dimethylformamide (DMF) and 1,4-dioxane was studied using agar ditch method. The results indicate that the compounds have the capacity to inhibit the growth of S. aureus and E. coli in varying concentrations. The inhibitory ability was influenced by the solvent and substituent group on the salicyldene fragment. | en_US |
| dc.identifier.citation | Dueke-Eze, Cordelia & Fasina, Tolu & Idika, Nne3Oma. (2011). Synthesis, electronic spectra and inhibitory study of some salicylaldehyde Schiff bases of 2-aminopyridine. Afr. J. Pure Appl. Chem.. 5. 13-18. | en_US |
| dc.identifier.issn | 1996 - 0840 | |
| dc.identifier.uri | https://ir.unilag.edu.ng/handle/123456789/4774 | |
| dc.language.iso | en | en_US |
| dc.publisher | African Journal of Pure and Applied Chemistry | en_US |
| dc.relation.ispartofseries | ;Vol. 5(2), pp. 13-18 | |
| dc.subject | Schiff base, 2,aminopyridine, keto-enol tautomerisim, inhibitory ability. | en_US |
| dc.subject | Research Subject Categories::NATURAL SCIENCES::Chemistry | en_US |
| dc.title | Synthesis, electronic spectra and inhibitory study of some salicylaldehyde Schiff bases of 2-aminopyridine | en_US |
| dc.type | Article | en_US |