Steroid responsive hypertension secondary to 11-beta hydroxylase deficiency--a case report

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dc.contributor.authorIsiavwe, A.R
dc.contributor.authorEkpebegh, C.O
dc.contributor.authorFasanmade, O.A
dc.contributor.authorOhwovoriole, A.E
dc.date.accessioned2020-01-15T12:05:51Z
dc.date.available2020-01-15T12:05:51Z
dc.date.issued2008-07
dc.descriptionStaff publicationsen_US
dc.description.abstractBACKGROUND: Congenital adrenal hyperplasia (CAH), due to deficiency in 11â hydroxylase enzyme is rare a cause of virilization associated with glucocorticoid responsive hypertension. OBJECTIVE: To present a rare cause of CAH and secondary hypertension responsive to glucocorticoid therapy. METHODS: Clinical and laboratory evaluation of a young woman with a" phallus" and hypertension. Investigations carried out included serum biochemistry, bone age determination, sex chromatin evaluation and serum levels of androgens and 17-OH progesterone, as well as pelvic ultrasonography. RESULTS: There was a history of cliteromegaly, first noticed at age 14 years, but menstrual periods were said to be regular. Physical findings included male type hairline and musculature with a blood pressure of 160/110mmHg. Breast development was Tanner Grade 3 while the public hair was male in pattern. The clitoris was 5cm long. Serum electrolytes were normal but levels of testosterone, dehydroepiandosterone sulphate and 17-OH progesterone were elevated. Features were compatible with a diagnosis of congenital adrenal hyperplasia (CAH) due to Il-beta-hydroxylase defficiency. Hypertension responded to glucocorticoid therapy, recurred on default and was corrected again on re-starting hydrocortisone. CONCLUSION: Congenital adrenal hyperplasia due to 11â-hydroxylase deficiency though rare, should be considered in the differential diagnosis of hypertension with virilization in young females.en_US
dc.identifier.citationIsiavwe AR, Ekpebegh CO, Fasanmade OA, Ohwovoriole AE. Steroid responsive hypertension secondary to 11-beta hydroxylase deficiency--a case report. West African Journal of Medicine, 2008;7(3);182-185.en_US
dc.identifier.issn0189160X
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/7408
dc.language.isoenen_US
dc.publisherWest African College of Physiciansen_US
dc.relation.ispartofseriesWest African Journal of Medicine;Vol.7(3)
dc.subjectCongenital adrenal hyperplasiaen_US
dc.subjectSecondary hypertensionen_US
dc.subjectSteroid responsiveen_US
dc.subjectResearch Subject Categories::MEDICINEen_US
dc.titleSteroid responsive hypertension secondary to 11-beta hydroxylase deficiency--a case reporten_US
dc.typeArticleen_US
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