Department of Biomedical Engineering
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Browsing Department of Biomedical Engineering by Author "Adejare, A. A."
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- ItemOpen AccessRelationship between Serum Retinol Concentrations with Severity of Malaria(The Nigerian Journal of Pharmacy, 2014-01-01) Nwoye, E. O.; Olayemi, S. O.; Oreagba, I. A.; Temiye, E. O.; Adejare, A. A.; Ojobor, P. D.Introduction: The effect of vitamin A supplementation in the reduction of childhood mortality has been known for some time however the more specific effect on malaria morbidity and mortality are less well documented. The objective of this study was to correlate serum retinol concentrations with severity of malaria using High Performance Liquid Chromatography Methods: Venous blood sample was taken for assay of baseline plasma retinol, packed cell volume and malaria parasite count patients between the ages of one and fifteen years with various severity of malaria ranging from moderate to severe malaria were selected to participate in the study. Result: Of 147 samples analysed, mean retinol levels did not correlate with parasite density but it correlated with the packed cell volume for all children with confirmed malaria parasite in their blood ( r=0.7469, Cl= 0.65 – 0.82, p=0.0001). Conclusion: Mean retinol level did not correlate significantly with parasite density but there is positive correlation between serum retinol and the packed cell volume
- ItemOpen AccessVitamin A Supplementation as an Adjunct in the Treatment of Mild to Moderate Childhood Malaria: Effect on Hematological Indices(The Nigerian Medical Practitioner, 2016-04-01) Nwoye, E. O.; Oreagba, I. A.; Temiye, E. O.; Olayemi, S. O.; Adejare, A. A.; Ojobor, P. D.Vitamin A supplementation to preschool children known to decrease the risks of mortality and morbidity from some forms of diseases such as diarrhea, measles, and human immunodeficiency virus (HIV) infection. These effects are likely to be the result of the actions of vitamin A on immunity. Therefore the role of Vitamin A supplementation in treatment of mild to moderate falciparum malaria in Nigerian children was investigated using haematological parameters as outcome indices. Eighty four (84) children between the ages of 6months and 12 years with fever and a positive Malaria Parasite result using Rapid Diagnostic Test were randomized and divided into two groups. Fifty four (54) patients received vitamin A supplementation in addition to a completeregimen of Artemether/lumefantrine given to both groups. Clinical and laboratory parameters (Malaria Parasite Density, WBC and PCV) were measured on day 0, 3, and 28. On the third day, both groups of patients were found to have complete Malaria Parasite clearance irrespective of Vitamin A supplementation. Vitamin A supplementation significantly increased mean White blood cell count (WBC) from 23.44 ± 10.57 % to 28.60 ± 8.62 % (p<0.05); it also increased mean White blood cell count (WBC) from 7080.00 ± 693.56cells/mm3 to 8711.11 ± 629.78cells/mm3 however this was not statistically significant (p>0.05). After treatment (on day 28) the mean PCV and WBC were significantly increased in both groups of patients (p<0.5). At baseline there was a significant (r=0.56) linear relationship between Malaria parasite density (MPD) and WBC while patients PCV showed no significant (r=0.41) linear relationship with MPD. Vitamin A plays a significant role as supplementation in the treatment of mild to moderate malaria by improving PCV and WBC laboratory indices: However (more comprehensive monitoring of Malaria Parasite Density within the first 48 hours of commencement of treatment is suggested