Department of Haematology and Blood Transfusion

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Browsing Department of Haematology and Blood Transfusion by Author "Adediran, A."

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    Open Access
    Hematologic Abnormalities in Treatment-Naïve HIV patients
    (Infectious Disease: Research and Treatment, 2010) Akinbami, A.; Oshinaike, O.; Adeyemo, T.; Adediran, A.; Dosumu, O.; Dada, M.; Durojaiye, I.; Adebola, A.; Osunkalu, V.
    Objectives: Hematologic abnormalities, indicated by a deranged full blood count, are common manifestations and important prognostic tools for human immunodeficiency virus (HIV) infection and AIDS. This study aimed to determine the prevalence of cytopenia and its relationship to the degree of immunosupression in HIV treatment-naïve patients. Methods: This was a cross-sectional study of treatment-naïve HIV-infected clients who enrolled at the HIV clinic of Lagos State University Teaching Hospital (LASUTH) between December 2009 and June 2010. Participants had samples taken for full blood count and CD4 counts, which are free routine pre-requisite and pre-treatment evaluations done for all registered HIV patients at LASUTH. They were asked to fill the structured questionnaires to obtain demographic data, with assistance if necessary. Results: A total of 205 cases were reviewed: 24.2% had anemia (PCV , 30%), 26.8% had leucopenia (white blood cell ,4,000/L) and 16.1% had thrombocytopenia (platelet count ,150,000/L) at enrollment. The degree of cytopenia was directly related to the degree of immunosupression. Conclusion: About one-fifth of HIV treatment-naïve patients were cytopenic at enrollment and the degree of cytopenia was directly related to the degree of immunosupression. It is necessary to investigate various causes of cytopenia in these patients so as to administer a specific intervention.
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    Open Access
    Homocysteine and folate levels as indicators of cerebrovascular accident
    (Journal of blood medicine, 2010) Osunkalu, VO.; Onajole, AT.; Odeyemi, KA.; Ogunnowo, BA.; Sekoni, AO.; Ayoola, GA.; Adediran, A.; Akinde, OR.; Adeyemo, AT.
    Background: Homocysteinemia has been established as a risk factor for cardiovascular disorders by the American Heart Association.1 Cerebrovascular accident (stroke) is presently ranked as one of the leading causes of morbidity and mortality worldwide. The aim of this study was to determine homocysteine and folate levels and some basic hematologic parameters in patients who sustain a cerebrovascular accident and those who do not. Methodology: In total, 100 participants were recruited, comprising 40 clinically diagnosed stroke (hemorrhagic or thromboembolic) patients and 60 healthy control subjects. Plasma homocysteine and folate levels were measured. Anticoagulated whole blood samples were evaluated for hemoglobin concentration (Hb), packed cell volume (PCV), white blood cell (WBC) count, and mean cell volume (MCV). Results: The mean age of stroke patients was 62 ± 12 years and that of controls was 55 ± 18 years (P = 0.1756). Mean plasma homocysteine levels for stroke patients and controls were 17.7 ± 4.4 µmol/L and 9.5 ± 2.4 µmol/L, respectively (P = 0.0000) and mean plasma folate levels for the groups were 6.5 ± 2.9 µg/dL and 4.0 ± 2.4 µg/dL (P = 0.0407). The MCV for stroke patients was significantly higher than that for controls (85 fl versus 82 fl, P = 0.04). Mean homocysteine levels correlated inversely with Hb and PCV (r = −0.08 and r = −0.122, respectively) and weakly with WBC (P = 0.125). Conclusion: Homocysteinemia is a major predictor of cerebrovascular accident in the black Nigerian population.
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    Open Access
    Homocysteine Levels in Nigerian Women with Pre-eclampsis/Eclampsia
    (Sierra Leone J Biomed Res, 2009) Osunkalu, V.O.; Akanmu, A.S.; Adediran, A.; Abudu, O.
    Hyperhomocysteinaemia has been linked in various studies worldwide to the occurrence of cardiovascular disorders and endothelial cell injury. In Nigeria with one of the highest maternal/neonatal mortality and morbidity, it is significant to explore means of predicting pregnancy-induced hypertension. This study was carried out at the Lagos University Teaching Hospital which is a major referral center in the South-western part of Nigeria. It was set to determine the mean plasma homocysteine levels and corpuscular haemoglobin in pre-eclamptic/eclamptic Nigerian women. A total of 150 subjects consisting of 100 primigravidae and 25 diagnosed cases of pre-eclampsia/eclampsia and 25 non-pregnant females were enrolled in the study. 60 primigravidae were lost to follow up or had incomplete data. The mean value of homocysteine in the control group, and eclamptic group was 7.5±3.4 µmol/L and 16.1±6.5 µmol/L respectively. There is positive and significant correlation between plasma homocysteine in the eclamptic group and the mean MCV (r=0.97, p=0.01), and between plasma homocysteine, systolic and diastolic blood pressure of the eclamptic group (r=0.944, p=0.0001; r=0.98, p=0.0001). The study further supports earlier findings of increased homocysteine levels in the occurrence of pre-eclampsia/eclampsia.
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    Open Access
    Homocysteine Levels in Nigerian Women with Pre-eclampsis/Eclampsia
    (Sierra Leone J Biomed Res, 2009-08) Osunkalu, V.O.; Akanmu, A.S.; Adediran, A.; Abudu, O.
    Hyperhomocysteinaemia has been linked in various studies worldwide to the occurrence of cardiovascular disorders and endothelial cell injury. In Nigeria with one of the highest maternal/neonatal mortality and morbidity, it is significant to explore means of predicting pregnancy-induced hypertension. This study was carried out at the Lagos University Teaching Hospital which is a major referral center in the South-western part of Nigeria. It was set to determine the mean plasma homocysteine levels and corpuscular haemoglobin in pre-eclamptic/eclamptic Nigerian women. A total of 150 subjects consisting of 100 primigravidae and 25 diagnosed cases of pre-eclampsia/eclampsia and 25 non-pregnant females were enrolled in the study. 60 primigravidae were lost to follow up or had incomplete data. The mean value of homocysteine in the control group, and eclamptic group was 7.5±3.4 µmol/L and 16.1±6.5 µmol/L respectively. There is positive and significant correlation between plasma homocysteine in the eclamptic group and the mean MCV (r=0.97, p=0.01), and between plasma homocysteine, systolic and diastolic blood pressure of the eclamptic group (r=0.944, p=0.0001; r=0.98, p=0.0001). The study further supports earlier findings of increased homocysteine levels in the occurrence of pre-eclampsia/eclampsia.
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    Open Access
    Urine methylmalonic acid levels in HIV-infected adults with peripheral neuropathy
    (Caspian Journal of internal medicine, 2013-05-05) Adediran, A.; Adeyemo, T.; Akinbami, A.; Osunkalu, V.; Akanmu, A.
    Background:Cobalamin deficiency and peripheral neuropathy (PN) are commonly seen in HIV-infected adults. The level of urine methylmalonicacid (UMMA), a reliableindicator of tissue cobalamin status, was determined in HIV infected subjects with and without PN to establish this association.Methods:One hundred and ninety-eight (198) consenting HIV infected subjects with and without PN were recruited for the study. UMMA level was determined by CationExchange High Performance Liquid Chromatography (HPLC) with Ultraviolet detector in 165 subjects. Simple proportions of patients with raised UMMA (defined as value> 3.4 mg in 24hr) were determined for each arm.Results:Among the 198 subjects studied, 146 had PNand52 had no PN. From the 165 subjects whose UMMA was studied, raised UMMA was found in 76.6% (36 of 47) of subjects with no PN as compared with 53.4% (63 of 118) of those with PN (p=0.018).Conclusion:Cobalamin deficiency (measured by UMMA level) even though common in HIV infected subjects, may not be the cause of peripheral neuropathyin these subjects.