Urine methylmalonic acid levels in HIV-infected adults with peripheral neuropathy
Caspian Journal of internal medicine
Background:Cobalamin deficiency and peripheral neuropathy (PN) are commonly seen in HIV-infected adults. The level of urine methylmalonicacid (UMMA), a reliableindicator of tissue cobalamin status, was determined in HIV infected subjects with and without PN to establish this association.Methods:One hundred and ninety-eight (198) consenting HIV infected subjects with and without PN were recruited for the study. UMMA level was determined by CationExchange High Performance Liquid Chromatography (HPLC) with Ultraviolet detector in 165 subjects. Simple proportions of patients with raised UMMA (defined as value> 3.4 mg in 24hr) were determined for each arm.Results:Among the 198 subjects studied, 146 had PNand52 had no PN. From the 165 subjects whose UMMA was studied, raised UMMA was found in 76.6% (36 of 47) of subjects with no PN as compared with 53.4% (63 of 118) of those with PN (p=0.018).Conclusion:Cobalamin deficiency (measured by UMMA level) even though common in HIV infected subjects, may not be the cause of peripheral neuropathyin these subjects.
Peripheral Neuropathy , Cobalamin deficiency , Urine methylmalonicacid (UMMA) , HIV infection , Research Subject Categories::MEDICINE
Adediran, A., Adeyemo, T., Akinbami, A., Osunkalu, V., Akanmu Alani (2013). Urine methylmalonic acid levels in HIV-infected adults with peripheral neuropathy. Caspian Journal of internal medicine, 4(3):707-711.