Department of Pharmacognosy

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https://ir.unilag.edu.ng/handle/123456789/3745

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Browsing Department of Pharmacognosy by Author "Adesegun, S."

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    Open Access
    Nigerian propolis: chemical composition, antioxidant activity and α-amylase and α-glucosidase inhibition
    (Taylor & Francis Group, 2019) Alaribe, C.S.; Esposito, T.; Sansone, F.; Adesegun, S.; Pagano, I.; Piccinelli, A.L.; Celano, R.; Rubio, O.C.; Coker, H.A; Nabavi, S.M.; Rastrelli, L.; Picerno, P.
    Propolis is an attractive natural ingredient to design health products due to its pharmacological effects. Our chemical investigation of a polar extract of Nigerian propolis (NP) led the isolation and identification of five isoflavonoids (1-4, 6), one diarylpropane (5) and one prenylated flavanone (7) by the combination of chromatographic and spectroscopic techniques. Compounds 1, 4and7 were found to be the main markers in NP (8.0, 5.0 and 4.0 mg/g of dry extract, respectively). Moreover, NP and its phenolic constituents exhibited in vitro free radical scavenging activity together with a promising antidiabetic effect againsta-amylase and a-glucosidase enzymes. Finally, NP showed also a moderate inhibitionof Helicobacter pylori growth. These results suggested that NP could be a good candidate in nutraceuticals and food products.