Pharmaceutical Chemistry- Scholarly Publications

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Properties of Complexes of 4-fluoroquinolones with iron (III).
(J. Pharm. Sci. & Pharmaceut. Prac., 1997) Adepoju-Bello A.A.; Eboka C.J.
A search through the literature of 4-fluoroquinolones was done as well as survey of its antibacterial activity. It was observed that the 4-fluoroquinolones are very potent antibacterial agents and that the activity is lowered by the co-administration of magnesium, iron (II) and iron (III) containing antacids and haematinics. The type of complex formed between iron (III) and 4-fluoroquinolones was observed to be 1:2 or 2:1 using ultraviolet/visible spectrophotometric method of analysis. It was established that the iron (Ill) complex of the 4-fluoroquinolones has a significantly lower antibacterial activity invitro compared with that of the pure 4-fluoroquinoione.