Department of Clinical Pharmacy and Biopharmacy

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Browsing Department of Clinical Pharmacy and Biopharmacy by Subject "Adherence"

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    Open Access
    Effect of 2 models of care and factors predicting patients' adherence to doctor's appointment attendance in Lagos State University Teaching Hospital, Ikeja, Lagos, Nigeria
    (SAGE, 2016) Aderemi-Williams, R.I.; Tayo, F.; Sagoe, A.; Zachariah, M.P.
    Background: Provision of antiretroviral therapy in resource limited settings has put pressure on the available infrastructure. Objectives: The study examined patients’ adherence to Doctor’s appointment attendance after an intervention changing the model of care and factors that predicted adherence. Methods: Observational study was carried out over four years. The model of care was changed in the last year and the effect assessed. SPSS version 15.0 was used for analysis. Predictors of adherence were determined using logistic regression model. Results: Over half 148 (59.7%) of the patients were females, with a mean age of 40.4+8.8 years and baseline CD4 cells of 143.5+92.7cells/microliters. ‘‘Adherence’’ rates were 51.3% in 2007, 35.9% in 2008 and 14.9% in 2009 giving patients’ average adherence to Doctor’s appointment attendance of 34.03%. Intervention changing the model of care in 2010 recorded an adherence rate of 93.1%. Conclusions: The change in model of care greatly improved patients’ ‘‘adherence’’. Patients’ knowledge of management, adherence, and smoking and drinking habits were identified as statistically significant predictors of adherence.
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    Open Access
    Medication Adherence and Influencing factors in Patients with Type 2 Diabetes attending a Tertiary Hospital in South West Nigeria.
    (2019) Onwuchuluba, E.E.; Soremekun, R.; Oyetunde, O.O.
    Background and Objectives: Adherence to anti-diabetic medications represents a huge hurdle that needs to be overcome for patients to gain maximum clinical benefits from their therapies. Several factors have been associated with patient adherence. This study assessed adherence to anti-diabetic medications and evaluated the influence of comorbid conditions and pill burden on adherence. Methods: This is a cross-sectional study of 418 consenting patients with established type 2 diabetes attending the Endocrinology outpatient clinic of a tertiary hospital. Patients were approached consecutively and surveyed using a questionnaire comprising of information on demographics, medication adherence, and factors affecting adherence. Data on medication regimen and comorbidities were extracted from participants’ case records. The study lasted for 15 months. Data were analyzed and summarized using descriptive and inferential statistics. Results: Nearly 27.5% of the participants were adjudged non-adherent to antidiabetic medications. The average number of antidiabetics was 1.56 ± 0.617. Of the number of participants that adherent, nearly 33 % and 35 % of them were on one and two antidiabetics respectively. However, been on three or more medications is associated with poorer adherence. Participants on Metformin had better adherence compared to those on insulin alone or insulin plus oral antidiabetics. Short duration of diabetes (p= 0.048), older age (p=0.024), high educational level (p=0.002) are associated with better adherence. Conclusion: A substantial number of patients were non-adherent to their anti-diabetic medications. Been prescribed 3 or more antidiabetic medications was associated with poor adherence. The association between adherence to medication and glycemic control was not significant. High Pill-burden, young age, low educational level are potential targets for interventions.
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    Open Access
    Medication Adherence in Type 2 Diabetes: A qualitative Exploration of Barriers and facilitators from socio ecological perspectives
    (Sage Publisher, 2021) Onwuchuluba, E.E.; Oyetunde, O.O.; Soremekun, R.O.
    Adherence to antidiabetic medications (ADMs) remains a serious challenge among type 2 diabetes mellitus (T2DM) patients. Factors affecting medication adherence are not fully understood in Nigeria. This qualitative study explored patients’ views on barriers and facilitators of medication adherence. Data collection was through face-to-face, semi-structured, in-depth interviews conducted on 25 purposively sampled patients attending a public tertiary hospital. The interviews were audio-recorded, transcribed verbatim, and analyzed using thematic analysis based on the socioecological framework. NVIVO version 10 identified more codes. The most commonly identified barriers were organizational (clinic structure), personal (perception of T2DM as a dangerous illness), interpersonal (lack of spousal support), and community (concerns about taking ADMs in social gatherings). It was observed that female patients received more spousal support than males. The facilitators of adherence include perceiving medication-taking as a routine, the need to live longer, having savings for ADMs, purchasing medications to last until the next clinic visit. This study identified barriers and facilitators unique to Nigerian T2DM patients. Interventions anchored on these factors would improve medication adherence.