Department of Pharmacognosy

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Browsing Department of Pharmacognosy by Subject "Antiglycation"

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    Open Access
    Antiglycation and Antioxidant Activity of Funtumia africana Root used in the Management of Diabetes
    (Tropical Journal of Natural Product Research, 2018) Nkemehule, F.E.; Ogbonnia, S.O.; Odukoya, O.A.
    Funtumia africana (Benth.) Stapf (Apocynaceae) is used folklorically for the treatment of various ailments such as dysentery, urinary incontinence, burns and diabetes. The aim of the study was to evaluate F. africana root hydroethanolic extract for the ability to inhibit formation of advanced glycation end-products and reactive oxygen species. The anti-glycation activity of the extract was determined using bovine serum albumin (BSA). Total phenolic content, total antioxidant capacity, ferric reducing antioxidant power (FRAP), nitric oxide (NO), lipid peroxide and 1, 1-diphenyl-2-picryl hydrazyl (DPPH) radical scavenging effects of the extract were also evaluated to determine the antioxidant activity. Result obtained, revealed that the extract significantly inhibited (P< 0.05) the formation of advanced glycation end-products (76.77%) at 100 µg/mL compared to aminoguanidine (85.76%). The total phenolic content was found to be 38.25 mg GAE/g and total antioxidant capacity 41.44 mg AAE/g of extract. DPPH, NO radical scavenging ability and FRAP of the extract were found to be concentration dependent (68.85%, 67.46% and 21.52 mg Fe2+/g respectively, at 100 µg/mL). The extract also exhibited good inhibition for lipid peroxidation in a concentration-dependent manner which was not significantly different from ascorbic acid (74.54% at 100 µg/mL). The antioxidant activity exhibited by the extract may be responsible for the observed inhibition of AGEs formation thus justifying the use of F. africana root in traditional medicine for the management of diabetes and its complications.