Basal and postglucagon C-peptide levels in Nigerians with type 2 diabetes mellitus
Date
2007-09
Authors
Coker, A.O
Fasanmade, O.A
Ohwovoriole, A.E
Journal Title
Journal ISSN
Volume Title
Publisher
Nigerian Society of Endocrinology and Metabolism
Abstract
Objective
To study basal C-peptide (BCP) and post glucagon C-peptide (PGCP) levels in Nigerians with type 2 diabetes mellitus.
Methods
A total of 40 subjects with type 2 diabetes and 20 control subjects were recruited from the Lagos University Teaching Hospital. BCP and PGCP were determined in all subjects.
Results
Mean+SEM BCP of 2.0+1.1ng/ml and 1.8+0.7 ng /ml in controls and subjects with diabetes was comparable. Mean +SEM post glucagon C-peptide (PGCP) and increment in C-peptide from basal was lower in subjects with diabetes compared with the control subjects (2.9 + 0.22 versus 5.6 + 0.5 and 1.14 +0.2 versus 3.6+0.32 respectively) p<0.05 and p<0.01. Among the subjects with diabetes, 2 had PGCP levels less than 1 ng/ml, and the mean increment in C-peptide was 0.03 and —0.06 ng/ml while 10(25%) had PGCP < 1.8ng/ml.
Conclusion
Post glucagon C-peptide levels are useful in reclassifying subjects Clinically defined as type 2 diabetes mellitus.
Description
Scholarly article
Keywords
C-peptide, post-glucagon, Nigerians , C-peptide , post glucagon C-peptide (PGCP) , type 2 diabetes mellitus. , Nigerians
Citation
Coker AO, Fasanmade OA, Ohwovoriole AE. Basal and post-glucagon C-peptide levels in Nigerians with type 2 diabetes mellitus. Nigerian Society of Endocrinology and Metabolism book of abstracts. Sept 2007.