Gigantism associated with hypopituitarism: a case report
Date
2007-09
Authors
Odeniyi, I.A
Adeyemi-Doro, A
Ekpebegh, C.O
Fasanmade, O.A
Awosanya, G.O
Ohwovoriole, A.E
Journal Title
Journal ISSN
Volume Title
Publisher
Nigerian Society of Endocrinology and Metabolism
Abstract
Background
Gigantism is a rare disorder, a major cause of which is hyperpituitarism. Even rarer is hyperpituitarism causing gigantism in the company of pituitary failure.
Objective
To present an unusual case of gigantism due to pituitary tumour in a patient who was also having features of hypopituitarism.
Case report
An 18-year-old male Nigerian diagnosed as having gigantism secondary to a pituitary adenoma is reported in this communication. He was referred from the orthopaedic clinic where he was being managed for a fracture. He was very tall compared with his siblings and peers. Pregnancy and early childhood were uneventful. He had excessive somnolence, sluggishness and weight gain. He weighed 114 kg with a height of 2.10m. His upper segment was 1.0m with a lower segment of 1.10m. The arm span was 2.32m. He had thick lips with large hands and feet. There was bilateral gynaecomastia with milky nipple discharge. He had scanty axillary hair but his pubic
hair distribution was Tanner stage 4. He had bitemporal hemianopia, diminished reflexes
globally, but no delayed relaxation phase of the ankle reflex. His pulse rate was 86bpm; his blood
pressure was 90/60mmbg. Basal growth hormone was markedly elevated. Basal Prolactin was
also elevated. Thyroid and testicular functions were impaired. Basal cortisol and stimulated
cortisol were equivocal. OGTT with serial growth hormone measurement showed no suppression
of growth hormone. imaging studies confirmed enlarged pituitary fossa due to pituitary tumour.
The problems with this patient were hyperpituitarism with hyperprolactinaemia, hypothyroidism,
hypogonadism and borderline adrenocortical function. He was commenced on bromocriptine and
hormonal replacement.
Conclusion
This case highlights delayed diagnosis and the concomitant presence of hyperpituitarism and
hypopituitarism. In the short term, patients can be controlled medically but long-term management
poses challenges.
Description
Nigerian Society of Endocrinology and Metabolism 2007
Keywords
Gigantism, hypopituitarism, Nigeria , Gigantism , Hypopituitarism , Nigeria
Citation
Odeniyi IA, Adeyemi-Doro AO, Ekpebegh CO, Fasanmade OA, Awosanya GO, Ohwovoriole AE. Gigantism associated with hypopituitarism: a case report. Abstract 4, Book of abstracts, Nigerian Society of Endocrinology and Metabolism 2007