Ossifying Fibroma: Clinico-Pathologic and Immuno-Histochemical Investigation of 157 Cases in a Tertiary Referral Centre
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Date
2017
Authors
Soyele, OO
Braimah, RO
Taiwo, AO
Ibikunle, AA
Gbotolorun, O.M.
Aregbesola, SB
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Abstract
Background: Ossifying Fibroma (OF) belong to a group of lesions known
as Fibroosseous lesions (FOL) whereby normal bone is replaced with fibrous
tissue containing abnormal bone. OF is the most common benign fibroosseous
lesions (FOLs) neoplasm of the oral and maxillofacial region.
Methodology: This is a retrospective study of cases of histologically
diagnosed maxillofacial OF in the department of Oral Biology and Oral
Pathology, Lagos University Teaching Hospital, Idi-araba, Lagos, from 1970
to 2009. Haematoxylin and Eosin (H and E), Masson’s Trichrome Stain and
AgNOR Stain were used to confirm the diagnosis of FD. Data was stored and
analysed using IBM SPSS Statistics for windows version 20 (Armonk, NY: IBM
Corp) and results presented in simple descriptive statistics and frequencies.
Result: One hundred and fifty seven cases of OF, representing 52.0%
of FOL were seen during the study period. OF was most commonly found in
the age group of 20-29 years with a mean age of 30.14 ± 13.72 years. OF
occur more frequently in females, 100 cases (63.69%) than males 57 cases
(36.31%) at a female to male ratio of 1.75:1. OF occur more commonly in
the mandible, 117 (74.52%) cases than maxilla 40 (25.48%) cases. High
proportion of lamellar bone (31% and above) was demonstrated by Masson’s
Trichrome Stain.
Conclusion: This present study showed a female predilection and that
OF was most commonly observed in the 3rd decade of life with mandibular
bone predilection. In addition, it showed presence of lamella bone as predictor
of OF using Masson’s trichrome (MT) stain.
Description
Scholarly article
Keywords
AgNOR stain , Ossifying fibroma , Fibroosseous lesions , Mixed bone trabeculae , Research Subject Categories::ODONTOLOGY
Citation
Soyele OO, Braimah RO, Ibikunle AA, Taiwo AO, Gbotolorun OM and Aregbesola SB. Ossifying Fibroma: Clinico-Pathologic and Immuno-Histochemical Investigation of 157 Cases in a Tertiary Referral Centre. RRJDS 2017; 5: 45-50.