Evaluation of Histomorphological, Toxicological and Antimicrobial Activities of Ethanolic Extract of Calliandra portoricensis Root in Rodents.
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Date
2017
Authors
Enwuru V.N
Ogbonnia S.O
Mbaka G.O
Emordi J.E
Ota D.A
Onyebuchi P.
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Abstract
Objective: To evaluate histomorphological, toxicological and antimicrobial activities of ethanolic
extract of Calliandra portoricensis root in rodents.
Introduction: C. portoricensis is usually administered for a lengthy period in treating diseases like dysmenorrheal, rheumatism and convulsion.
Methods: Microbial purity was evaluated on some bacterial and fungal organisms. Toxicity of the
extract was evaluated in Swiss albino mice by administering graded oral doses of the extract from
1.0 to 20.0 g/kg body weight (bwt). Wistar rats were fed different doses of the extract for 30 days to
evaluate their biochemical profiles while vital organs were processed for histology.
Results: Extract inhibited Enterococcus faecalis and Streptococcus pneumonia ATCC 49619
organisms at 150, 300 and 600 mg/ml with the inhibitory diameters of 13.0, 14.0 and 16.0 mm for
E. faecalis and 10.0, 11.0 and 13.0 mm for S. pneumonia. Median acute toxicity (LD50) was 5.0
g/kg bwt. Significant increase (p≤ 0.05) in aspartate aminotransferase and alanine
aminotransferase occurred while hepatic tissue morphology showed sinusoidal and portal
congestions. Also significant increase (p≤ 0.05) in the plasma creatinine and urea occurred.
Conclusion: C. portoricensis showed to be an effective antibacterial agent and exhibited no toxic
effect at normal dose. However administration above the recommended dose might be injurious to
the liver.
Description
Scholarly article
Keywords
Calliandral portoricensis , anti-microbial , toxicological , histo-morphological , rodents , Research Subject Categories::PHARMACY
Citation
Enwuru VN, Ogbonnia SO, Mbaka GO, Emordi JE, Ota DA and Onyebuchi P (2017). Evaluation of Histomorphological, Toxicological and Antimicrobial Activities of Ethanolic Extract of Calliandra portoricensis Root in Rodents; J. Pharm. Research International, 18(5): 1-13.