Suppressive and curative antiplasmodial properties of nauclea latifolia against erythrocytic stage of mice infective chloroquine sensitive Plasmodium berghei NK-65
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Date
2020-01-01
Authors
Alaribe, S.C.
Oladipupo, A.
Nani, M.
Ijeoma, I.
Olanipekun, B.
Coker, H.A
Journal Title
Journal ISSN
Volume Title
Publisher
Journal of Medicinal Plants for Economic Development. JOMPED
Abstract
Background: Malaria remains a devastating disease, particularly in the tropics, where it is the
highest killer of pregnant women and children under the age of 5 years. Significant efforts and
resources have been vested in malaria control and eradication programmes, but the
unavailability of malaria vaccine and the emergence of resistance of malaria parasite to existing
antimalarial drugs have continued to hamper attempts at controlling or eradicating the
disease. This warrants the development of new antimalarial drugs. Nauclea latifolia root is
widely applied for malaria treatment in Nigeria.
Aim: This study investigated the antimalarial property of N. latifolia roots.
Setting: N. latifolia roots were collected from Ikwuano, Umuahia, Abia State, Nigeria.
Methods: To extract the bioactive constituents, an aqueous infusion of the plant was prepared
and fractionated by solvent-solvent extraction with n-hexane, ethyl acetate and butanol,
respectively. Antimalarial property was evaluated using suppressive and curative assays in
mice infected with chloroquine-sensitive Plasmodium berghei NK-65 strain.
Results: The extract and fractions produced significant suppressive and curative antiplasmodial
activities ( p < 0.05). The aqueous extract and n-hexane and butanol fractions gave 85.22%,
84.52% and 91.32% chemosuppression, respectively, which were comparable to that of
chloroquine used as positive control. The extract and fractions gave considerable curative
effects in the range 52.23% – 77.00%.
Conclusion: These findings indicate that N. latifolia roots possess antimalarial property and
reflect its ethnomedicinal use for malaria treatment. Thus, N. latifolia roots may be exploited
for development of herbal formulations and isolation of novel bioactive compounds for
malaria treatment.
Description
Scholarly article
Keywords
antimalarial , antiplasmodial , suppressive activity , Nauclea latifolia , Plasmodium berghei , Research Subject Categories::PHARMACY
Citation
Alaribe, C., Oladipupo, A., Nani, M., Ijeoma, I., Olanipekun, B., & Coker, H. (2020). Suppressive and curative antiplasmodial properties of Nauclea latifolia root extract and fractions against erythrocytic stage of mice-infective chloroquine-sensitive Plasmodium berghei NK-65. Journal of Medicinal Plants for Economic Development, 4(1), 6 pages. doi:https://doi.org/10.4102/jomped.v4i1.72