Anatomic and Molecular Pathology- Scholarly Publications
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- ItemOpen AccessEnteromyeloschisis. A rare sacro - Enteric mass in the newborn(Journal of Pediatric Surgery Case Reports, 2020-01) Ladipo-Ajayi, Oluwaseun; Ihediwa, George; Jolayemi, Edward; Haruna, Muibah; Alakaloko, Felix; Seyi-Olajide, Justina; Abdulkareem, Fatimah; Okezie, KanuA lumbosacral appendage in a newborn is a source of extreme anxiety for parents. While sacral masses are the most common solid tumours of the newborn (1 in 20–45,000 live births), true caudal appendages (human tails) are rare [1,2]. Sacral masses are frequently teratomas which are composed of multiple tissues alien to their site of origin, derived from more than 1 germ layer. Rarer pathologies like neuroenteric cysts or true caudal appendages (human tail) have been sparsely reported in literature [3,4]. We present an extremely rare case of a sacral mass of complete gastrointestinal origin and discuss possible aetiology and differentials. We have coined the term ''Enteromyeloschisis'' to describe this lesion as our search of the English literature did not show a report of any similar case where the tail was made up entirely of bowel.
- ItemOpen AccessEnteromyeloschisis. A rare sacro - Enteric mass in the newborn(Journal of Pediatric Surgery Case Reports, 2020-11) Abdulkareem, FB; Ladipo-Ajayi, O.; Ihediwa, G.; Jolayemi, E.; Haruna, M.; Alakaloko, F; Seyi-Olajide, J; Kanu, O.Introduction A lumbosacral appendage in a newborn is a source of extreme anxiety for parents. While sacral masses are the most common solid tumours of the newborn (1 in 20–45,000 live births), true caudal appendages (human tails) are rare [1,2]. Sacral masses are frequently teratomas which are composed of multiple tissues alien to their site of origin, derived from more than 1 germ layer. Rarer pathologies like neuroenteric cysts or true caudal appendages (human tail) have been sparsely reported in literature [3,4]. We present an extremely rare case of a sacral mass of complete gastrointestinal origin and discuss possible aetiology and differentials. We have coined the term ''Enteromyeloschisis'' to describe this lesion as our search of the English literature did not show a report of any similar case where the tail was made up entirely of bowel.
- ItemOpen AccessMorphological Pattern of Childhood Solid Tumours in Lagos University Teaching Hospital.(Nigerian Quarterly Journal of Hospital Medicine, 2009) Akinde, O.R; Abdukareem, F.B; Daramola, A.O; Anunobi, C.C; Banjo, A.A.FBackground: There is a wide variation in the incidence of childhood tumors world wide. The relative incidence of childhood tumors in developing countries is increasing and might add significantly to the high childhood morbidity and mortality caused by infectious diseases. There is need to determine the incidence of childhood cancer in different centers of the country and contribute to the National cancer register Objective: The aim of this study is to determine the burden and patterns of childhood tumour in our environment. Methods: A retrospective review of histologically diagnosed cases of childhood tumours seen from January 2000 to 2007 from the records of the department of Morbid Anatomy of the Lagos University Teaching Hospital (LUTH), Nigeria was carried out. All the cases were analyzed for age and gender distribution as well as histological types Results: Malignant tumours constituted 30.50% of the tumours of which retinoblastoma is the most common. The most common benign tumour was fibroadenoma accounting for 36.2% of all benign tumours. The female to male ratio for malignant and benign tumours are 1:1 and 1:1.3 respectively. The peak age incidence was 11 – 15 years for benign and 1 – 5 for malignant tumours. . Conclusion: The study showed decrease in the annual incidence of childhood tumours in Lagos. There was however no difference in the pattern when compared with other centers in Nigeria and in other African countries.
- ItemOpen AccessEFFECT OF BRIDELIA FERRUGUBEA STEM BARK ON BLOOD CHEMISTRY AND HISTOLOGY OF SOME ORGANS IN RATS(Nigerian Journal of Natural Products and Medicine, 1998) Ofogba, CJ; Agbomo, FU; Abdul-Kareem, FB; Abaelu, AM; Alatishe, KAqueous extract of Bridelia ferruginea stem bark caused significant increases in serum K+, creatinine, total bilirubin, GOT, GPT, HDL, Alkaline phosphate, BUN (p<0.001) and decreases in serum Na+, Cl-, CO2), cholesterol, glucose, Ca2+ (p<0.01,0.001) in rats. No changes were observed in serum triglyceride, uric acid, phosphate and total protein levels when compared with the control. The increase in some if these parameter was detected by means of PAS staining. The heart and lungs also showed adverse effects.
- ItemOpen AccessPrognostic factors in the management outcome of carcinoma of the larynx in Lagos.(Nigerian Postgraduate Medical Journal, 2003) Somefun, OA; Nwawolo, CC; Okeowo, PA; Alabi, SB; Abdul-Kareem, FB; Banjo, AA; Elesha, SOThis is a retrospective analysis on the prognostic factors in the management outcome of clinically and histologically diagnosed carcinoma of larynx seen in Lagos University Teaching Hospital between 1996-1999. Various prognostic factors have been documented as determinants on the probable outcome of carcinoma of the larynx, such as duration of symptoms, smoking, medical status of the patient, degree of differentiation, size and site of tumour and presence of cervical lymph node. Thirty-six patients between 1996-1999 were reviewed, with a male to female ratio of 11:1, and peak age group of occurrence in 50-59 years, majority (86.12%) of which were non-smokers who presented in varied degrees of airway obstruction necessitating pre-treatment tracheostomy in 70% of the patients with more than 50% presenting within 3-6 months of onset of initial symptom. The tumours were staged clinically and histology revealed well differentiated T3 glottic tumour without any clinically palpable neck node in more than 50% of the patients which should predict a better outcome. But the interplay of many prognostic variables like pre-treatment tracheostomy and its attendant complications, supposed biological aggressive tumour in a non-smoker, coupled with treatment biased by patients, high costs of treatment, logistics and poor follow up compliance, resulted in poor outcome of our management.