Oral and Maxillofacial Pathology/Biology - Scholarly Publications

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    Open Access
    Odontogenic tumors: analysis of 289 Nigerian cases
    (1995-11) Odukoya, O.
    Two hundred and eighty-nine cases of odontogenic tumors that accumulated in the files of the biopsy service of the Lagos University Teaching Hospital during a period of 21 years were analysed and categorised according to the most recent WHO classification of odontogenic tumors. Odontogenic tumors constituted 19% of all oral/jaw tumors and tumor-like lesions. Ameloblastoma, which accounted for 58.5% of odontogenic tumors in the series, was the most common, and showed a predilection for males and the posterior mandible. 94.8% of odontogenic tumors were benign, while malignant odontogenic tumors accounted for 5.2%). Odontogenic carcinoma was the most prevalent malignant odontogenic tumor; it showed a predilection for the mandible and occurred at a mean age of 37 year
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    Open Access
    Desmoplastic Ameloblastoma: Analysis of 17 Nigerian Cases
    (2011) Effiom, O.A.; Odukoya, O.
    Objective. This study aimed to add to existing knowledge on 90 cases of desmoplastic ameloblastoma (DA) previously reported in the scientific literature and analyze data that could help speculate on its biologic profile. Study design. From 330 cases of ameloblastoma (pooled from 573 histologically diagnosed odontogenic tumours) 17 cases of DA were retrieved and analyzed for estimated mean growth rate (EMGR) and histologic variants. EMGR for DA was compared with EMGR for conventional ameloblastoma (CA), as recorded over the same period of 38 years. Results. Desmoplastic ameloblastoma had predilection for mandible (81.2%), posterior mandible being the most commonly affected, contrary to scientific literature reports of anterior maxillary predilection. Simple DA (88.0%) and DA with osteoplasia (12.0%) were the histologic variants observed. EMGR for DA (0.36 0.44 cm/mo) was significantly less than EMGR (0.71 1.16 cm/mo) for CA (P .000480). Conclusion. This study speculates that DA tends to be less biologically aggressive than CA and has predilection for posterior mandible in Nigerians
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    Open Access
    Periapical granuloma associated with extracted teeth
    (2011-03-21) Omoregie, F.O.; Ojo, M.A.; Saheeb, B.D.; Odukoya, O.
    Objective: This article aims to determine the incidence of periapical granuloma from extracted teeth and correlate the clinical diagnoses with the histopathological types of periapical granuloma. Patients and Methods: Over a period of eight months, a prospective study designed as a routine biopsy of recoverable periapical tissues obtained from patients who had single tooth extraction was carried out. Results: One hundred and thirty-six patients participated in the study, with 75 (55.1%) histopathologically diagnosed periradicular lesions. There were 23 (16.9%) cases of periapical granuloma, with a male to female ratio of 2: 1. The lesion presented mostly between the third and fourth decades of life (n=9, 6.6%). Clinically diagnosed acute apical periodontitis was signifi cantly associated with periapical granuloma, with predominantly foamy macrophages and lymphocytes (P<0.05). Conclusion: Periapical granuloma appears to be a less common periapical lesion in this study compared to the previous reports. In contrast to reports that relate to an acute fl are of the lesion with abundant neutrophilic infi ltration, this study has shown marked foamy macrophages and lymphocytes at the acute phase, which are signifi cantly associated with the clinical diagnosis of acute apical periodontitis. We recommend the classifi cation of periapical granuloma into early, intermediate, and late stages of the lesion, based on the associated infl ammatory cells
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    Open Access
    Osseo-integration in spontaneously regenerated hemi-mandible
    (2011-10-28) Omorege, O.F.; Ojo, M.A.; Saheeb, B.D.; Odukoya, O.
    Objective: This article aims to determine the incidence of periapical granuloma from extracted teeth and correlate the clinical diagnoses with the histopathological types of periapical granuloma. Patients and Methods: Over a period of eight months, a prospective study designed as a routine biopsy of recoverable periapical tissues obtained from patients who had single tooth extraction was carried out. Results: One hundred and thirty-six patients participated in the study, with 75 (55.1%) histopathologically diagnosed periradicular lesions. There were 23 (16.9%) cases of periapical granuloma, with a male to female ratio of 2: 1. The lesion presented mostly between the third and fourth decades of life (n=9, 6.6%). Clinically diagnosed acute apical periodontitis was significantly associated with periapical granuloma, with predominantly foamy macrophages and lymphocytes (P<0.05). Conclusion: Periapical granuloma appears to be a less common periapical lesion in this study compared to the previous reports. In contrast to reports that relate to an acute flare of the lesion with abundant neutrophilic infiltration, this study has shown marked foamy macrophages and lymphocytes at the acute phase, which are significantly associated with the clinical diagnosis of acute apical periodontitis. We recommend the classification of periapical granuloma into early, intermediate, and late stages of the lesion, based on the associated inflammatory cells.
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    Open Access
    Two-phase carcinogenesis in hamster buccal pouch
    (Elsevier Inc., 1982-11) Odukoya, o; Shklar, G
    A two-phase mechanism of chemical carcinogenesis in hamster buccal pouch has been demonstrated. Painting of buccal pouches three times weekly with a 0.1 percent solution of 7,12-dimethylbenz(a)anthracene (DMBA) in mineral oil for 10 weeks resulted in no visible tumors nor any microscopic evidence of dysplasia after the animals had been maintained for a 20 week period (Group 1 animals). Painting with 0.1 percent DMBA for 10 weeks, no treatment for a following 6 week period, and painting with 0.5 percent DMBA for a subsequent 4 weeks resulted in epidermoid carcinomas (Group 2 animals). Painting with 0.1 percent DMBA for 4 weeks in animals without prior treatment resulted in no tumors (Group 3 animals). It is postulated that the early treatment in Group 2 may serve for initiation and the later treatment for promotion.