Histopathological Effects of Paint Effluent on Swiss Albino Mice (Mus musculus)
Date
2018
Authors
Oladele, E.O
Adewumi, O.O
Yahaya, T
Taiwo, I.A.
Journal Title
Journal ISSN
Volume Title
Publisher
Nigerian Journal of Pure and Applied Sciences. Faculty of Physical Sciences and Faculty of Life Sciences, Univ. of Ilorin, Nigeria
Abstract
Industrial effluents are seen as the most potential and hazardous waste containing compounds like
heavy metals and nutrients that are toxic. In this study, the compositions of effluent from a paint
industry were assessed along with its histopathological effects on the Swiss albino mice. The effluent
was taken from Golden Key Paints found along Lagos State University (LASU) Road, Akesan, Lagos.
Twenty (20) laboratory mice were obtained from Nigerian Institute of Medical Research, Yaba, Lagos.
There were four mice (a male and three females) in each group comprising of five groups. Group one
was the control group. They were given distilled water, while groups 2 to 5 had 25, 50, 75 and 100 %
v/v of the paint effluent, respectively as the single source of water. By the 4th week, the control mice
had live birth of 12 young mice (babies) while the mice treated with paint effluent had no birth. It was
observed that at least a mouse died in each cage of the treated group. These observations could be
attributed to the treatment concentrations. Histopathological examination of the tissues of treated mice
showed severe necrosis and fibromatosis colli of the kidney, hepatic necrosis of the liver, lung atrophy,
tubular atrophy of the heart, loss of myocardial striation and tissue hyalination due to the concentrations
of the effluents. These results express the harmful effects of paint effluent on the treated mice and are
sensitive index to changes in ecological conditions. This can serve as a good diagnostic tool in
toxicological studies. People are therefore advised to handle paints with care and keep them away from
children.
Description
Staff Publications
Keywords
Hepatic Necrosis , Tissue hyalination , Atrophy , Anomaly , Research Subject Categories::NATURAL SCIENCES
Citation
Oladele E.O, Adewumi, O.O, Yahaya, T, and Taiwo I.A. (2018): “Histopathological Effects of Paint Effluent on Swiss Albino Mice (Mus musculus)’’. Nig. Journal of Pure and Appl. Science (NJPAS). Faculty of Physical Sciences and Faculty of Life Sciences, Univ. of Ilorin, :31 (2). 3212-3219.