Antioxidant activities of different solvent extracts of leaves and root of Flabellaria paniculata Cav. (Malpighiaceae)
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Date
2012-08-15
Authors
Sofidiya, M.O.
Familoni, O.B.
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Journal ISSN
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Publisher
academic journals.org
Abstract
The antioxidant activities of different solvent extracts of the leaves (ethanol (FLE), aqueous (FLH),
chloroform (FLC)) and root (ethanol (FRE), aqueous (FRH) and chloroform (FRC)) of Flabellaria
paniculata were screened by different methods using free radical scavenging against DPPH and
hydroxyl radicals, ex vivo lipid peroxidation, ferrous ion chelating activity, reducing power and total
antioxidant capacity in phosphomolybedum assay. The extracts (10 to 100 µg/ml) showed varying
degrees of antioxidant activity in different test systems. The leaves and root extracts showed
significant inhibition of lipid peroxidation and scavenging of hydroxyl radicals. The extracts also
showed moderate chelating property which could explain the affinity of the extracts for iron (Fe), hence
their antioxidant capability. However, in DPPH radical scavenging and reducing power assays, FRE
extract had higher activity than all the extracts, and the activity is comparable to that of quercetin and
tocopherol at higher concentrations (80 to 100 µg/ml) of the extract used in this study. Flavonoid
content of different extracts of F. paniculata is in the order FLE>FLC>FRE>FRC>FRH>FLH. Ethanol
extracted the highest root amount of condensed tannin (216.42 ± 0.018 mg equivalent of catechin/g of
extract), while proanthocyanidin contents of leaf extracts varied from 12.7 to 47.9 mg of gallic acid
equivalence (GAE)/g extract. No correlation was observed between DPPH, Fe chelating, lipid
peroxidation, reducing power, and total phenolic contents of the extracts. However, proanthocyanidin
content was moderately correlated with chelating (R² = 0.43) and DPPH radical scavenging (R² = 0.7811)
activities. Hence, these extracts could be considered as natural antioxidants and may be useful for
curing diseases arising from oxidative deterioration.
Description
Staff publications
Keywords
Research Subject Categories::NATURAL SCIENCES::Chemistry::Organic chemistry::Bioorganic chemistry , Flabellaria paniculata Cav , Antioxidant , polyphenolic contents , solvent extraction , leaves , root
Citation
Sofidiya, M. O., & Familoni, O. (2012). Antioxidant activities of different solvent extracts of leaves and root of Flabellaria paniculata Cav.(Malpighiaceae). Journal of Medicinal Plants Research, Vol.6(31), 4682-4690pp.