Assessment of Rational Prescribing of Antihypertensive drug combination in Lagos University Teaching Hospital

Nwoye, E.O. ; Oreagba, I.A. ; Olayemi, S.O. ; Mabodeje, A.F. (2004-06-01)

Staff publications


Purpose: The study aimed to assess prescribing trends of antihypertensive and production of prescriptions containing irrational combinations of antihypertensives and co-prescribed drugs. Methods: Five hundred and fifty four prescriptions, containing antihypertensives, were collected prospectively over a period of twelve months, from the internal medicine clinic of the Lagos University Teaching Hospital and evaluated. Results: the average number of drugs prescribed per encounter was 2.0. Encounters with injections were 0.5%. The percentage of drugs prescribed by generic name was 31.6%. All the drugs prescribed were from the National Essential Drug List. Calcium antagonists were the most frequently used group o f drug (41.3%), followed by Diuretics (33.0%) and Anglotensin-Converting Enzyme inhibitors (ACEIC) (22.4%). Nifedipine (31.9%), Methyldopa (22.4%) and propranolol (20.2%) were the most frequently used individual drugs. Beta-blockers with Calcium antagonists (13.3%), Methyldopa with Diuretics (10.6%) Calcium antagonists with ACEIs (10.3%) were the most frequently prescribed drug combinations. Irrational drug combinations with NSAIDs were observed in 21.8% of the prescriptions. Also beta-blockers were prescribed in 22% of prescriptions for hypertensive / diabetic patients. Conclusion: There is need to educate prescribers on appropriate therapeutic combinations that would provide optimal management of hypertension and associated clinical conditions