Insulin resistance and cardiovascular risk in older adult Nigerians with type 2 diabetes.
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Date
2019-01-01
Authors
Udenze, I.C.
Taiwo, I.A.
Minari, J.B.
Adeyemo, W.L.
Journal Title
Journal ISSN
Volume Title
Publisher
Wolters Kluwer
Abstract
Background: Insulin resistance (IR), which refers to decreased metabolic response to normal concentrations of insulin, has been
associated with increasing age and is a trigger to the cascade of cardiometabolic abnormalities hence increasing cardiovascular disease
(CVD) risk in elderly populations with type 2 diabetes (T2D). Strategies targeting IR may be key to mitigating excess CVD morbidities
in elderly patients with T2D.
Aim: The aim of this study is to evaluate the relationship between IR and CVD and also to identify cardiometabolic risk (CMR) factors
as primary targets of CVD reduction in the older populations of Nigerians with T2D.
Settings and Design: Lagos, Nigeria. Cross‑sectional, analytical.
Subjects and Methods: A total of 363 adult Nigerians with T2D aged between 40 and 100 years old were consecutively recruited
for this study. T2D was defined according to the WHO criteria. Data were collected using a questionnaire and fasting blood samples
were collected for analysis.
Statistical Analysis Used: The data were analyzed using the IBM SPSS statistical package. Statistical significance was set at value
of P < 0.05.
Results: T2D patients in the age group of 60–80 years had significantly higher blood pressure than those in the younger age
group, (P = 0.009). Fasting plasma glucose (FPG) and glycated hemoglobin were the highest in the age group of 40–60 years, (P = 0.016).
IR was associated with older age in the T2D (P = 0.026). IR showed a significant correlation with CMR factors. Multivariate regression
showed FPG to be independently associated with IR (P = 0.003).
Conclusion: IR correlated with CMR factors and was independently associated with FPG, re‑emphasizing focus on short‑term blood
glucose control in elderly diabetic populations.
Description
Keywords
Cardiometabolic risk , Cardiovascular disease risk , Insulin resistance , Type 2 diabetes
Citation
Udenze IC, Taiwo IA, Minari JB, Adeyemo WL. Insulin resistance and cardiovascular risk in older adult Nigerians with type 2 diabetes. Int J Non‑Commun Dis 2019;4:21-6.