Prevalence Of Prostate Cancer Among Nigerians With Intermediate Total Prostate Specific Antigen Levels (4-10ng/Ml): Experience At Lagos University Teaching Hospital, Nigeria
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Date
2012
Authors
Ezenwa, E.V.
Tijani, K.H.
Jeje, E.A.
Ogunjimi, M.A.
Journal Title
Journal ISSN
Volume Title
Publisher
ISPUB
Abstract
Prostate cancer is a common clinical condition among adult males world wide1
; its prevalence in the intermediate total PSA values (4-10ng/ml) has not been assessed among Nigerians. This study was carried out to determine the prevalence of prostate cancer among patients with intermediate total PSA values seen in Lagos University Teaching Hospital (LUTH), a tertiary hospital located in Nigeria. A total number of 105 patients aged 50years and above with total PSA values within the intermediate PSA range (4-10ng/ml) and normal findings of the prostate on digital examination seen from January 2010 to December 2010 were recruited for the study. These patients had no features suggestive of metastasis on clinical examination. All the patients subsequently had free PSA assay and trans-rectal guided six core biopsy of the prostate. The mean age of the patients studied was 64.4years (SD=1.6) with mean total PSA value of 6.6ng/ml (SD=1.7). One hundred patients (95.1%) presented with lower urinary tract symptoms. The prostate cancer rate following analysis of biopsy specimen was 13.3 % ( 14 patients) with most patients (78.6%) within 61-70 year old bracket. The histology was adenocarcinoma in all the patients; Gleason scores 5-7 predominating. We therefore concluded that the prevalence of prostate cancer among Nigerian males with intermediate total PSA and palpably benign prostate gland from this study is 13.3%. Awareness of the prevalence of prostate cancer in this range should be created among Nigerians, as this will help improve the overall management of prostate cancer patients in this category.
Description
Staff publications
Keywords
prostate cancer , Prostate specific antigen , Free PSA , intermediate zone of PSA , Research Subject Categories::MEDICINE::Surgery
Citation
Ezenwa E, Tijani K, Jeje A, Ogunjimi A, Ojewola R. Prevalence Of Prostate Cancer Among Nigerians With Intermediate Total Prostate Specific Antigen Levels (4-10ng/Ml): Experience At Lagos University Teaching Hospital, Nigeria. The Internet Journal of Urology 2012;9(3):1-5