Physicotechnical, spectroscopic and thermogravimetric properties of powdered cellulose and microcrystalline cellulose derived from groundnut shells.
No Thumbnail Available
Date
2012
Authors
Azubuike, C.P.
Odulaja, J.
Okhamafe, A.O.
Journal Title
Journal ISSN
Volume Title
Publisher
International Pharmaceutical Excipients Council of the America
Abstract
α-Cellulose and microcrystalline cellulose powders, derived from agricultural waste products, that have for the pharmaceutical industry, desirable physical (flow) properties were investigated. α–Cellulose (GCN) was extracted from groundnut shell (an agricultural waste product) using a non-dissolving method based on inorganic reagents. Modification of this α -cellulose was carried out by partially hydrolysing it with 2N hydrochloric acid under reflux to obtain microcrystalline cellulose (MCGN). The physical, spectroscopic and thermal properties of the derived α-cellulose and microcrystalline cellulose powders were compared with Avicel® PH 101, a commercial brand of microcrystalline cellulose (MCCA), using standard methods. X-ray diffraction and infrared spectroscopy analysis showed that the α-cellulose had lower crystallinity. This suggested that treatment with 2N hydrochloric acid led to an increase in the crystallinity index.
Thermogravimetric analysis showed quite similar thermal behavior for all cellulose samples, although the α- cellulose had a somewhat lower stability. A comparison of the physical properties between the microcrystalline celluloses and the α-cellulose suggests that microcrystalline cellulose (MCGN and MCCA) might have better flow properties. In almost all cases, MCGN and MCCA had similar characteristics. Since groundnut shells are agricultural waste products, its utilization as a source of microcrystalline cellulose might be a good low-cost alternative to the more expensive commercial brand.
Description
Staff publications
Keywords
Agricultural residue , Groundnut shell , Microcrystalline cellulose , Physicotechnical properties , Thermal properties , Research Subject Categories::PHARMACY
Citation
Azubuike C.P., Odulaja J. O. & Okhamafe A. O. (2012). Physicotechnical, spectroscopic and thermogravimetric properties of powdered cellulose and microcrystalline cellulose derived from groundnut shells. J. Excipients and Food Chem., 3 (3):106-115.