In vitro antisickling, antimicrobial and antioxidant potentials of extracts of Sorghum bicolor (L) Moench seeds and Mangifera indica (L) Anacardiaceae leaves and their formulations
No Thumbnail Available
Date
2016-12
Authors
Azubuike, C.P.
Uzoeto, C.A.
Igbokwe, N.H.
Igwilo, C.I.
Journal Title
Journal ISSN
Volume Title
Publisher
Nigerian Association of Pharmacists in Academia, University of Benin Branch, Benin City, Nigeria.
Abstract
Purpose: Seeds of Sorghum bicolor (SB) and leaves of Mangifera indica (MI) are used in ethnomedicine in the management of sickle cell disorder (SCD). The present study involves phytochemical analysis of the methanolic extracts of the plant parts and evaluation of their antibacterial, antioxidant and antisickling potentials as well as syrups containing the extracts.
Methods: Phytochemical analysis of the methanolic extracts were evaluated using standard methods while the functional groups were elucidated using Fourier transform infrared spectroscopy (FT-IR). Antioxidant properties were determined by comparing their radical scavenging activity against gallic acid and ascorbic acid while antibacterial properties of the plant extracts were evaluated against Salmonella typhi, Pseudomonas aeruginosa, Escherichia coli andStaphylococus auerus. The syrups containing the extracts were evaluated and compared to CiklavitÉ.
Results: Phytochemical screening and FI-TR spectra the presence of bioactive molecules including flavonoids and phenols. The two extracts had comparable antioxidant properties however, only Mangifera indica extract had antibacterial activity against tested organisms. Both extracts including their syrup formulation had antisickling activity with the syrup containing 500 mg SB and 250 mg MI having superior activity.
Conclusion: Sorghum bicolor seeds and Mangifera indica leaves extracts and their formulations might play a great role in the management of SCD.
Description
Staff publications
Keywords
Antisickling , Antioxidant , Antimicrobial , Mangifera indica , Sorghum bicolor , Research Subject Categories::PHARMACY
Citation
Azubuike C. P., Uzoeto, C. A., Igbokwe N. H., Igwilo, C. I. (2016). In vitro antisickling, antimicrobial and antioxidant potentials of extracts of Sorghum bicolor (L) Moench seeds and Mangifera indica (L) Anacardiaceae leaves and their formulations. Journal of Science and Practice of Pharmacy, 3 (1): 135-144.