Prolactin and Dehydroepiandrosterone (DHEA) in Nigerian Females
Date
2004
Authors
Ajayi, G.O
Omilabu, S
Adegbola, O
Wellington, J
Adeyemi, R
Journal Title
Journal ISSN
Volume Title
Publisher
Nigerian Society of Endocrinology and Metabolism
Abstract
Objective: To evaluate whether there is any correlation between P/ olaclin and dehydroepiandrosterone (DHEA) level in Nigerian women being managedfor infértility.
Setting: Gynaecological Outpatient Clinic of the Lagos University Teaching Hospital (LUTH).
Subjects: Eighty one women investigated for infertilityfrom July 2002 10 July 2003 had their blood ussuyedfor prolaclin and DHEA.
Results: The mean prolactin level of 15.17±13.88ng/ml was slightly higher than acceptable high limit of normal (15ng/ml) with 28.4% ofwomen accounting for this high value. The mean DHEA was 12.51±9.6Sng/ml and also higher (25% higher) than acceptable high limit of normal (9.8ng/ml) with 43.2% ofthese women accounting for this high value. There was a strong correlation between prolactin and DHEA (R = 0.06; P values = 0.033196) Conclusion: Prolaclin rise is associated Wilh subsequent rise ofDHEA and possibly other adrenal androgens which may potentiate the suppression of ovarian function ofprolactin. It is recommended that serum androgens should be assayed whenever there is a high Prolactin level.
Description
Staff publications
Keywords
Prolactin , Dehydroepiandrosterone , Infertility , Patients , Research Subject Categories::MEDICINE::Surgery::Obstetrics and women's diseases::Obstetrics and gynaecology
Citation
Ajayi, G.O. Omilabu, S. Adegbola, O. Wellington, J. Adeyemi, R. Prolactin and Dehydroepiandrosterone (DHEA) in Nigerian Females. African Journal of Endocrinology and Metabolism 2004:5(1):9-11.