Prolactin and Dehydroepiandrosterone (DHEA) in Nigerian Females

Ajayi, G.O ; Omilabu, S ; Adegbola, O ; Wellington, J ; Adeyemi, R (2004)

Staff publications

Article

Objective: To evaluate whether there is any correlation between P/ olaclin and dehydroepiandrosterone (DHEA) level in Nigerian women being managedfor infértility. Setting: Gynaecological Outpatient Clinic of the Lagos University Teaching Hospital (LUTH). Subjects: Eighty one women investigated for infertilityfrom July 2002 10 July 2003 had their blood ussuyedfor prolaclin and DHEA. Results: The mean prolactin level of 15.17±13.88ng/ml was slightly higher than acceptable high limit of normal (15ng/ml) with 28.4% ofwomen accounting for this high value. The mean DHEA was 12.51±9.6Sng/ml and also higher (25% higher) than acceptable high limit of normal (9.8ng/ml) with 43.2% ofthese women accounting for this high value. There was a strong correlation between prolactin and DHEA (R = 0.06; P values = 0.033196) Conclusion: Prolaclin rise is associated Wilh subsequent rise ofDHEA and possibly other adrenal androgens which may potentiate the suppression of ovarian function ofprolactin. It is recommended that serum androgens should be assayed whenever there is a high Prolactin level.