Chemical composition, gastroprotective and antioxidant activities of Schrebera arborea fruits
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Date
2020
Authors
Sofidiya, M.O.
Bamigbade, O.
Basheeru, K.
Adegoke, O.
Agunbiade, F.O.
Journal Title
Journal ISSN
Volume Title
Publisher
Taylor & Francis
Abstract
The chemical composition, gastroprotective, and antioxidant activities of Schrebera arborea fruits were investigated. The solvent extracts were analyzed for fatty acid and polyphenolic content using gas chromatography-mass spectrometry (GC–MS) and high performance liquid chromatography (HPLC), respectively. Acute toxicity study was done by oral administration at 2,000 mg kg–1. Gastroprotective effect was evaluated at 50, 100, or 150 mg kg–1 in ethanol and indomethacin- induced ulcer models in rats. The antioxidant activities of the extract were also evaluated. Sitosterol (41.55%) was the major component identified by GC–MS. Quantitative HPLC analysis for phenolic compounds indicated the presence of gallic acid (0.19 mg g–1), caffeic acid (0.13 mg g– 1), rutin (0.30 mg g–1), apigenin-7-glucoside (1.21 mg g–1), catechin (1.84 mg g–1), and kaempferol (6.53 mg g–1), respectively.
The ethanolic extract of the fruit produced 63.5% and 80.8% inhibition of ethanol and indomethacin-induced ulcer
at 100 mg kg–1, respectively. The extract at 100 mg kg–1 reduced MDA level and increased glutathione, catalase, and
superoxide dismutase activities in rat stomach tissue. Significant radical scavenging antioxidant activity was recorded in vitro.
Description
Scholarly articles
Keywords
HPLC analysis , Schrebera arborea , Gas chromatography-mass spectrometry , Chemical composition
Citation
Margaret Oluwatoyin Sofidiya, Olaoluwa Bamigbade, Kazeem Basheeru, Olufunmilayo Adegoke Foluso O. Agunbiade (2020). Chemical composition, gastroprotective and antioxidant activities of Schrebera arborea fruits. Journal of Herbs, Spices and Medicinal Plants, 26(1), 89-100.