Impact of pregnancy on glucose and insulin homeostasis

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Okunowo, B.O
Idris, M
Odeniyi, I.A
Fasanmade, O.A
Okunowo, A
Oluwole, A
Ohwovoriole, A.E
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International Society of Endocrinology/SEMDSA
Introduction: Several studies have reported glucose homeostasis in pregnant Nigerian Women, However, few of those studies have reported on the insulin or pancreatic c-peptide homeostasis in pregnancy. Aim: To determine the effect of pregnancy on basal and stimulated plasma glucose, insulin, and glucose homeostasis. Methods: Clinical data obtained from each participant included height, pre-pregnancy weight, gestational age, and chronological age. During a standard oral glucose tolerance test, blood was sampled for determination of fasting and 2h post-challenge plasma levels of glucose, insulin, and c-peptide. We compared basal and stimulated values of glucose, plasma insulin, c-peptide, HOMAR IR, beta-cell function, insulin secretion, and glucose-insulin ratio (GIR) of the pregnant versus non-pregnant women. The level of statistical significance was set at p<0.05. Results: Fifteen pregnant women at 24 to 28 weeks gestation and ten non-pregnant Nigerian women were studied. The two groups were similar in age and pregnancy body mass index. The mean FPG value of the nonpregnant was higher than that of the pregnant women (p>0.05). The non-pregnant women also had higher values of FCP and stimulated GIR. Values of insulin resistance, beta-cell function, insulin secretion, c-peptide, and fasting GIR were all significantly higher in pregnancy. Conclusion: In the basal state, nonpregnant Nigerian women have higher plasma glucose concentrations. Pregnancy results in higher values of stimulated plasma glucose, insulin, and c-peptide concentrations. The findings of this report are likely to be due to the state of increased insulin resistance associated with pregnancy.
Scholarly articles
Pregnancy , Diabetes , Glucose , Insulin , Homeostasis , Research Subject Categories::MEDICINE
Okunowo BO, Idris M, Odeniyi IA, Fasanmade OA, Okunowo A, Oluwole A, Ohwovoriole A. Impact of pregnancy on glucose and insulin homeostasis. Abstract 283. International Society of Endocrinology/SEMDSA book of abstracts 2018