FTIR Solid State Interaction of Moxifloxacine With Metals

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Olaitan O.J.
Adepoju-Bello A.A.
Kasim L.S.
Ibitoye S.F.
Fagbohun A.B.
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African Journal of Science & Nature
In this research, metal salts containing K , Zn , Cu and Al were used to study the interaction of metal ions with moxifloxacin HCl using Solid state synthesis. The result obtained using Fourier Transform Infrared -1 Spectra, showed a perturbation of the absorption band of the carbonyl groups at around 1700cm-1 in Moxifloxacin HCl when it was triturated in solid state synthesis with Zn ,Cu and Al ,indicating an interaction with these metal ions. This interaction was however absent in K because the peak was evident at - 1708.2 cm-1. These interactions may have an effect on therapeutic outcome of co-administration of moxifloxacin HCl with antacids or agents containing metal ions. Keywords: Quinolones, Moxifloxacin, Carbonyl groups, Metals ions, bidentate, polydentate.
Scholarly articles
Quinolones , Moxifloxacin , Carbonyl groups , Metal ions , Research Subject Categories::PHARMACY::Pharmaceutical chemistry
Olaitan OJ, Adepoju-Bello AA., Kasim, LS, Ibitoye SF., Fagbohun AB (2015). FTIR Solid State Interaction of Moxifloxacine With Metals. African Journal of Science & Nature Vol. 1, 12-15 (2015)