Phenolic contents, antioxidant and antibacterial activities of Hymenocardia acida

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dc.contributor.authorSofidiya, M.O.
dc.contributor.authorOdukoya, O.A.
dc.contributor.authorAfolayan, A.J.
dc.contributor.authorFamiloni, O.B.
dc.date.accessioned2021-04-27T13:15:29Z
dc.date.available2021-04-27T13:15:29Z
dc.date.issued2009
dc.descriptionScholarly articlesen_US
dc.description.abstractThis study investigates the antioxidant and antibacterial activities of aqueous and methanolic extracts from Hymenocardia acida Tul. (Hymenocardiaceae). The inhibition values of the extracts and quercetin were found to be very close, with no significant differences at a concentration of 0.05 mg mL-1 in their ability to inhibit 1,1-diphenyl-2-picrylhydrazyl (DPPH). Total proanthocyanidins for both water and methanol extracts were 20.2 ±0.01 and 30.6 ±0.51 mg g-1 (catechin equivalent) while the total phenol contents were 20.0 ±0.52 and 35.6 ±1.42 mg mL-1 (tannic acid equivalent), respectively. Positive correlations R2 =0.85, R2 = 0.94, R2 =0.97 for DPPH, reducing power and 2’-azino-bis (3-ethylbenzo thiazoline) 6-sulphonic acid (ABTS). Linear regression analysis also produced a high correlation coefficient with total proanthocyanidins (DPPH, R2 = 0.69; ABTS, R2 = 0.94). H. acida extracts showed low antibacterial activity (minimum inhibitory concentration (MIC) value ≥5.0 mg mL-1) against gram negative bacteria but significantly (MIC value ≥2.5 mg mL-1) inhibited the growth of the gram positive strains tested. Qualitative TLC of the extract was positive for flavonoids, phenols, steroids and triterpenoids. The results of this study support the use of H. acida in traditional Nigerian medicine and show that the alcoholic extract of the leaves can be used as an easily accessible source of natural antioxidant and can be of assistance in some dermatological problems.en_US
dc.identifier.citationMargaret O. Sofidiya, Olukemi A. Odukoya, Anthony J. Afolayan, Oluwole B. Familoni (2009). Phenolic contents, antioxidant and antibacterial activities of Hymenocardia acida. Natural Product Research 23, 168-177.en_US
dc.identifier.issn1478-6427
dc.identifier.urihttps://ir.unilag.edu.ng/handle/123456789/9379
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofseriesNatural Product Research;23
dc.subjectHymenocardia acidaen_US
dc.subjectAntioxidant activityen_US
dc.subjectAntibacterial activityen_US
dc.subjectPolyphenolsen_US
dc.subjectResearch Subject Categories::PHARMACY::Pharmacognosyen_US
dc.titlePhenolic contents, antioxidant and antibacterial activities of Hymenocardia acidaen_US
dc.typeArticleen_US
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